逐瘀通痹汤治疗膝骨性关节炎临床观察  

Zhuyu Tongbi Decoction in the Treatment of Knee Osteoarthritis

作　　者：黄伟 李继 陈洪议 HUANG Wei;LI Ji;CHEN Hongyi(Department of Surgery,Dongxiang District Second People’s Hospital,Jiangxi Province,Fuzhou 331800,China)

机构地区：[1]抚州市东乡区第二人民医院外科,江西抚州331800

出　　处：《中国中医药现代远程教育》2024年第23期58-61,共4页Chinese Medicine Modern Distance Education of China

摘　　要：目的探讨膝骨性关节炎(KOA)患者应用逐瘀通痹汤治疗的效果。方法采用随机数字表法将2020年10月—2022年10月于抚州市东乡区第二人民医院就诊的KOA患者94例分为两组,各47例。对照组予常规西医治疗,观察组在对照组基础上加用逐瘀通痹汤治疗,均治疗12周。对比两组临床疗效、中医证候积分、炎症因子水平、膝关节功能及不良反应。结果观察组临床总有效率为95.74%(45/47),高于对照组的80.85%(38/47)(P<0.05)。治疗后,观察组中医证候积分、西安大略麦克马斯特大学骨关节炎指数量表(WOMAC)评分及肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均低于对照组(P<0.05)。结论KOA患者应用逐瘀通痹汤治疗,可减轻关节炎症,改善膝关节功能,效果显著,安全性好,值得临床推广应用。Objective To explore the effect of modified Zhuyu Tongbi decoction on knee osteoarthritis(KOA)patients.Methods A total of 94 patients with KOA who were treated in Dongxiang District Second People’s Hospital from October 2020 to October 2022 were divided into two groups by random number table,with 47 patients in each group.The control group was treated with conventional Western medicine,and the observation group was treated with Zhuyu Tongbi decoction for 12 weeks.The clinical efficacy,TCM syndrome score,inflammatory factor level,knee joint function and adverse reactions were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 95.74%(45/47),which was higher than that of control group(80.85%,38/47)(P<0.05).After treatment,TCM syndrome scores,Western Ontario and McMaster University Osteoarthritis Index(WOMAC)scale scores and tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)levels in observation group were lower than those in control group(P<0.05).Conclusion Modified Zhuyu Tongbi decoction can reduce arthritis and improve knee function in KOA patients,has significant effect and good safety,and is worthy of clinical application.

关 键 词：痹证 膝骨性关节炎 风寒湿痹 逐瘀通痹汤 中医药疗法 

分 类 号：R274.9[医药卫生—中西医结合]