基于母胎免疫失衡探讨不明原因复发性流产的中西医发病机制  

Discussion on the Pathogenesis of Unexplained Recurrent Spontaneous Abortion in Traditional Chinese Medicine and Western Medicine Based on Maternal-placental Immune Imbalance

作　　者：马倩 王克华[2] MA Qian;WANG Kehua(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China;Department of Reproduction and Genetics,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250014 [2]山东中医药大学附属医院生殖与遗传中心,山东济南250014

出　　处：《中国中医药现代远程教育》2024年第23期184-187,共4页Chinese Medicine Modern Distance Education of China

基　　金：山东省自然科学基金面上项目【No.ZR2021MH256】。

摘　　要：复发性流产(RSA)严重威胁着生育期女性的生殖健康,是困扰许多孕龄期女性的难题。目前有关RSA发生机制的探讨甚多,免疫影响是相当关键的一环。与免疫紊乱相关的RSA包括自身免疫和同种免疫两种类型,而同种免疫型RSA的发生与母胎免疫失衡排斥胚胎有关,故也被称为不明原因复发性流产(URSA)。URSA归属于中医学“滑胎”范畴,以“肾虚、气血亏虚、血瘀、情志不畅”为主要病因病机。文章基于母胎免疫耐受失衡综述URSA的中西医发病机制,期望为其临床诊疗提供理论参考。Recurrent spontaneous abortion(RSA)is a problem that afflicts the vast body of pregnant women,which seriously threatens the reproductive health of pregnant women.At present,there are many theories about the mechanism of RSA,and the immune effect is also critical.RSA related to immune disorders includes two types:autoimmune and alloimmune.The occurrence of RSA of alloimmune type is related to the imbalanced maternal-placental immune tolerance rejecting the embryo,so it is also called Unexplained Recurrent Spontaneous Abortion.In traditional Chinese medicine,unexplained recurrent spontaneous abortion(URSA)is called“habitual abortion”,with“kidney deficiency,deficiency of qi and blood,blood stasis,emotional depression”as its main etiology and pathogenesis.This review will explore the pathogenesis of URSA of traditional Chinese medicine and Western medicine based on maternalplacental immune tolerance imbalance,hoping to provide theoretical reference for the clinical diagnosis and treatment of RSA.

关 键 词：滑胎 不明原因复发性流产 母胎免疫失衡 发病机制 综述 

分 类 号：R714.21[医药卫生—妇产科学]