Exploration of potential mechanisms for the treatment of ulcerative colitis by Solanum diphyllum L.based on network pharmacology and molecular docking  

作　　者：Kexin Huang Nan Yang Bingxin Zhang Ziqi Sun Xiaoshu Zhang 

机构地区：[1]Faculty of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Journal of Polyphenols》2024年第4期165-175,共11页多酚杂志（英文）

摘　　要：Evidence of the advantages of Solanum nigrum L.for the treatment of ulcerative colitis is accumulating.However,research revealing the treatment of Solanum diphyllum L.against ulcerative colitis is scarce.In this study,the chemical components of the extract of Solanum diphyllum L.were characterized by LC-MS/MS,identifying 31 compounds by positive and negative total ion flow maps.A total of 425 component target genes and 1900 disease target genes were obtained,and 121 intersection targets and 6 core targets were obtained after the intersection of the two genes by means of network pharmacology.GO analysis and KEGG analysis respectively obtained 20 signaling pathways such as anti-infl ammation.The results of molecular docking showed that the chemical components could successfully dock with the target proteins of the disease such as SRC,EGFR,PTGS2,MMP9,HSP90AA1,ESR1.This study provided a scientifi c basis for the development and application of Solanum diphyllum L.

关 键 词：LC-MS/MS ulcerative colitis Solanum diphyllum L. network pharmacology molecular docking 

分 类 号：R285[医药卫生—中药学]