L-瓜氨酸治疗新生儿持续性肺动脉高压的潜在价值  

Potential value of L-citrulline in the treatment of persistent pulmonary hypertension of the newborn

作　　者：杨星月 钟隽镌 许芳[1] 叶秀桢[1] Yang Xingyue;Zhong Junjuan;Xu Fang;Ye Xiuzhen(National Key Clinical Specialty Construction Project/Department of Neonatology,Guangdong Women and Children Hospital,Guangdong Neonatal Intensive Care Unit Medical Quality Control Center,Guangzhou 511400,China)

机构地区：[1]国家临床重点专科建设项目单位/广东省妇幼保健院新生儿科,广东省新生儿重症医学专业质量控制中心,广州511400

出　　处：《中华实用儿科临床杂志》2024年第12期943-946,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家重点研发计划(2021YFC2701704)。

摘　　要：新生儿持续性肺动脉高压(PPHN)是新生儿期的一种常见急危重症,以持续性肺动脉高压和低氧血症为特征,病死率较高。公认的治疗方法除呼吸机支持有效通气外,还需要应用肺血管扩张药物,如吸入一氧化氮、西地那非等,各有其优势。近年来,L-瓜氨酸作为一种治疗选择,在PPHN治疗中显示出巨大的潜力。本文旨在探讨L-瓜氨酸治疗PPHN方面的可能潜力,从治疗机制、药代动力学、研究现状和未来展望等方面进行综述。Persistent pulmonary hypertension of the newborn(PPHN)is a common and critical disease in the neonatus characterized by persistent pulmonary hypertension and hypoxemia,with a high mortality.Except for intubation and ventilator support,recognized treatments often require the application of pulmonary vasodilators drugs,such as inhaled nitric oxide,Sildenafil,etc,each with its own advantages.In recent years,L-citrulline,as a potential therapeutic option,has shown huge potential in PPHN treatment.The purpose of this review is to explore the possible potential of L-citrulline in the treatment of PPHN in terms of therapeutic mechanism,pharmacokinetics,current status of research and future perspectives.

关 键 词：婴儿 新生 持续性肺动脉高压 L-瓜氨酸 治疗 

分 类 号：R722.1[医药卫生—儿科]