泰乐菌素生物合成及代谢调控研究进展  

Advances in the Biosynthesis and Metabolic Regulation of Tylosin

作　　者：陈晨[1] 张传波 苏建宇[2] 卢文玉[1] CHEN Chen;ZHANG Chuanbo;SU Jianyu;LU Wenyu(School of Chemical Engineering and Technology,Tianjin University,Frontier Science Center for Synthetic Biology and Key Laboratory of System Bioengineering(Tianjin University),Ministry of Education,Tianjin 300350,China;College of Life Science,Ningxia University,Key Laboratory of Conservation and Utilization of Special Biological Resources in the Western,Ministry of Education,Yinchuan 750021,China)

机构地区：[1]天津大学化工学院、教育部合成生物学前沿科学中心、系统生物工程教育部重点实验室,天津300350 [2]西部特殊生物资源保护与利用教育部重点实验室、宁夏大学生命科学学院,银川750021

出　　处：《中国生物工程杂志》2024年第11期99-109,共11页China Biotechnology

基　　金：宁夏回族自治区重点研发计划(2021BEG02003)资助项目。

摘　　要：泰乐菌素是由弗氏链霉菌发酵产生的16元环大环内酯类抗生素,可用于预防和治疗革兰氏阳性菌所引发的细菌感染,在畜牧业应用广泛,具有较高的经济效益和学术研究价值。介绍了泰乐菌素的结构特征和作用机制,并重点综述了弗氏链霉菌生产泰乐菌素的生物合成调控机制、高产菌株选育,以及泰乐菌素的异源生物合成策略的研究进展,为深入了解泰乐菌素生物合成及代谢调控提供有益借鉴。Tylosin,a 16-membered macrolide antibiotic produced by Streptomyces fradiae,is used in clinical practice primarily to treat bacterial infections caused by Gram-positive bacteria.It is widely used in animal husbandry and has high economic value and academic research value.The structural features and mechanism of tylosin are presented.The research progress in the biosynthesis regulation mechanism,the breeding of high-yield strains of S.fradiae and tylosin heterologous biosynthesis strategy are summarized,which will provide a useful reference for in-depth understanding of tylosin biosynthesis and metabolic regulation.

关 键 词：泰乐菌素 弗氏链霉菌 生物合成 代谢调控 菌株改造 

分 类 号：Q819[生物学—生物工程]