蛋白质组学在中医药防治心肌梗死后心力衰竭疾病研究中的应用进展  

Proteomics in prevention and treatment of post-myocardial infarction heart failure diseases with traditional Chinese medicine

作　　者：张丰荣 张颖[1] 杨济丞 李贤煜[1] 杨洪军[1,2] ZHANG Feng-rong;ZHANG Ying;YANG Ji-cheng;LI Xian-yu;YANG Hong-jun(Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院医学实验中心,北京100700 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2024年第22期6008-6018,共11页China Journal of Chinese Materia Medica

基　　金：中国中医科学院医学实验中心“中药复杂作用解析协同创新”团队课题(XTCX2023001);国家自然科学基金面上项目(82174238)。

摘　　要：心肌梗死(MI)是临床上高致残率和高致死率的心血管疾病,其后续可演变为心力衰竭(HF)或心脏破裂等并发症。蛋白质组学能从整体水平、分子水平系统地、通量化追踪疾病发生发展过程中相关功能分子的改变。利用蛋白质组学技术深度挖掘MI和HF的功能靶标、分子机制、网络效应,将有助于该疾病的早期诊断、提前预警和药物治疗。近年来,中药在防治MI后HF方面取得了显著进展,特别是通过蛋白质组学技术阐明中药的复杂作用机制。该文系统综述了蛋白质组学在中药复方及其活性成分对MI后HF干预机制的研究,以及相关体内通路的探索。此外,该文还讨论了蛋白质组学在蛋白生物标志物的挖掘、蛋白质翻译后修饰、蛋白质-蛋白质相互作用、空间蛋白质组学等研究,以期推动蛋白质组学技术在中药心血管疾病防治中的深入应用。Myocardial infarction(MI)is a cardiovascular disease with high disability and mortality rates in clinical practice,which can subsequently develop into complications such as heart failure(HF)or cardiac rupture.Proteomics can track changes in relevant functional molecules during the occurrence and progression of diseases from an overall,molecular,systematic,and flux perspectives.Utilizing proteomic techniques to deeply explore the functional targets,molecular mechanisms,and network effects of MI and HF can aid in early diagnosis,early warning,and drug treatment of these diseases.In recent years,significant progress has been made in the prevention and treatment of HF following MI using traditional Chinese medicine(TCM),particularly in elucidating the complex mechanisms of action through proteomic techniques.This article systematically reviewed research on the intervention mechanisms of TCM compound prescriptions and their active ingredients in HF after MI,and explored related in vivo pathways.Additionally,it discussed the role of proteomics in protein biomarker discovery,post-translational modifications of proteins,protein-protein interactions,spatial proteomics,and more,with the aim of advancing the deep application of proteomic techniques in the prevention and treatment of cardiovascular diseases with TCM.

关 键 词：蛋白质组学 心肌梗死 心力衰竭 中药 

分 类 号：R259[医药卫生—中西医结合]