芸香科植物生物碱类化学成分及药理作用研究进展  

Research progress in alkaloids and their pharmacological effects from plants of Rutaceae

作　　者：陈秋娟 粟晓微 张慧婷 李睿 刘雨玲 周华锋 苏健 霍丽妮 CHEN Qiu-juan;SU Xiao-wei;ZHANG Hui-ting;LI Rui;LIU Yu-ling;ZHOU Hua-feng;SU Jian;HUO Li-ni(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200

出　　处：《中国中药杂志》2024年第22期6030-6047,共18页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(22067001);广西自然科学基金项目(2023GXNSFAA026476);广西中医药大学“岐黄工程”高层次人才团队培育项目(202405);广西中医药大学“桂派中医药传承创新团队”项目(2022B005)。

摘　　要：芸香科植物在我国广泛分布,药用历史悠久,其化学成分含有种类繁多的生物碱,类型主要包括异喹啉类、喹啉类、吖啶酮类、咔唑类、吲哚类等,药理研究表明芸香科植物生物碱大多具有抗肿瘤、抗炎、抗病毒、抗糖尿病等活性。该文对从芸香科植物中分离得到的378个生物碱类化学成分及药理作用进行归纳总结,以期为未来的药物开发和植物资源的可持续利用提供科学依据。The plants of Rutaceae,with wide distribution in China,have a long history of medicinal use.They contain a wide variety of alkaloids,which include isoquinolines,quinolines,acridones,carbazoles,and indoles.Pharmacological studies have shown that most of these alkaloids have antitumor,anti-inflammatory,antiviral,antidiabetic and other activities.This article summarized 378 alkaloids isolated from plants of Rutaceae and their pharmacological effects,aiming to lay a basis for future drug development and sustainable utilization of plant resources.

关 键 词：芸香科 生物碱 药理作用 抗肿瘤 抗炎 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]