重构本草——益智仁  

Reconstruction of Chinese Materia Medica-sharp-leaf glangal fruit

作　　者：康梦娇 汤梓晗 赵林华[3] 张伟 KANG Mengjiao;TANG Zihan;ZHAO Linhua;ZHANG Wei(The First Clinical Medical School,Zhejiang Chinese Medical University,Hangzhou 310053,China;College of Integrated Chinese and Western Medicine,Hebei Medical University,Shijiazhuang 050031,China;Institute of Metabolic Diseases,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;School of Basic Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]浙江中医药大学第一临床医学院,杭州310053 [2]河北医科大学中西医结合学院,石家庄050031 [3]中国中医科学院广安门医院代谢病研究所,北京100053 [4]甘肃中医药大学基础医学院,兰州730000

出　　处：《长春中医药大学学报》2024年第12期1317-1319,共3页Journal of Changchun University of Chinese Medicine

基　　金：中国科学院学部咨询评议项目(2021-ZW10-A-017);国家自然科学基金面上项目(81973837)。

摘　　要：通过古籍文献调研、中药现代研究进展及其研究成果的梳理,结合中医临床及中药学等学科领域专家学者的认识及应用经验,经讨论认为益智仁:功效主要为暖肾固精缩尿、温脾开胃摄唾。症靶为多尿、流涎。现代药理研究认为,益智仁及其有效成分具有抑菌、调节排尿、保护肾脏、抗肿瘤、镇痛、镇静催眠、保护心血管、抗溃疡、调节胃肠、抗过敏、抗氧化、抗衰老、改善记忆力、保护神经等作用。本品无毒,但阴虚火旺或因热而患遗滑崩带者忌服。临床常用剂量为5~30g,内服时根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索益智仁与症靶的量效关系构建。Through investigation of ancient books and the sorting of the research progress and modern research achievements of traditional Chinese medicine,combined with the understanding and application experience of experts and scholars in desciplinary fields such as traditional Chinese medicine clinical medicine and science of Chinese materia medica,it is concluded that sharpleaf glangal fruit mainly has the effects of warming the kidneys,controlling nocturnal emission by literal meaning and reducing urination,warming spleen,appetizing flavor and absorbing saliva.The symptom targets are polyuria and salivation.Modern pharmacological studies have found that sharp-leaf glangal fruit and its active ingredients have antibacterial,urinary regulation,kidney protection,anti-tumor,analgesic,sedative hypnotic,cardiovascular protection,anti ulcer,gastrointestinal regulation,anti allergy,antioxidant,anti-aging,memory improvement,and nerve protection effects.This product is non-toxic,but it should be avoided for those with hyperactivity of fire due to yin deficiency,or those who suffer from nocturnal emission and metrorrhagia and metrostaxis.The clinical dosage is 5-30g.When taken orally,it should be used based on syndrome differentiation according to different diseases or different stages of the same disease,and the construction of dose-effect relationship between the dosage of sharp-leaf glangal fruit and the symptom target should be explored actively.

关 键 词：益智仁 症靶 重构本草 临床回归 

分 类 号：R282[医药卫生—中药学]