Nrf2、LXA4、TGF-β在结核性胸膜炎胸膜纤维化中的表达及相关性分析  

Expression and correlation analysis of nuclear factor E2 related factor 2,lipoxin A4 and transforming growth factor-βin pleural fibrosis of tuberculous pleurisy

作　　者：孔康宝 朱建坤 徐洋 刘大伟 王成 KONG Kangbao;ZHU Jiankun;XU Yang;LIU Dawei;WANG Cheng(Department of Thoracic Surgery,Shandong Provincial Public Health Clinical Center,Jinan 250100,China;Department of Interventional Radiology,Shandong Provincial Public Health Clinical Center,Jinan 250100,China)

机构地区：[1]山东省公共卫生临床中心胸外科,济南250100 [2]山东省公共卫生临床中心介入科,济南250100

出　　处：《长春中医药大学学报》2024年第12期1384-1388,共5页Journal of Changchun University of Chinese Medicine

基　　金：山东省医药卫生科技发展计划项目(202104020663)。

摘　　要：目的探究核因子E2相关因子2(Nrf2)、脂氧素A4(LXA4)、转化生长因子-β(TGF-β)在结核性胸膜炎(TBP)胸膜纤维化中的表达及相关性。方法选取2021年6月-2023年6月在山东省公共卫生临床中心收治的结核性胸膜炎患者80例,根据是否合并胸膜纤维化分对照组(未合并胸膜纤维化)和研究组(合并胸膜纤维化),根据肺功能分为轻度、中度和重度减退组。结果研究组血清Nrf2、LXA4、TGF-β、胸膜厚度显著高于对照组(P<0.05),1秒用力呼气容积(FEV1)、用力肺活量(FVC)和FEV1/FVC显著低于对照组(P<0.05);轻度、中度和重度肺功能减退组血清Nrf2、LXA4、TGF-β、胸膜厚度依次升高(P<0.05);Pearson相关性分析血清Nrf2、LXA4、TGF-β均与FEV1、FVC和FEV1/FVC和胸膜厚度有关(P<0.05);多因素Logistic回归分析显示,Nrf2、LXA4、TGF-β是影响结核性胸膜炎胸膜纤维化的危险因素(P<0.05);ROC曲线分析显示,血清Nrf2、LXA4、TGF-β联合诊断结核性胸膜炎胸膜纤维化的AUC为0.934,三者联合优于各自单独诊断(均P<0.05)。结论结核性胸膜炎患者中血清Nrf2、LXA4、TGF-β显著升高,三者与肺功能和胸膜厚度有关,联合检测可提高对结核性胸膜炎胸膜纤维化的诊断价值。Objective To investigate the expression and correlation of nuclear factor E2 related factor 2(Nrf2),lipoxin A4(LXA4),and transforming growth factor-β(TGF-β)in tuberculous pleurisy(TBP)with pleural fibrosis.Methods 80 patients with TBP admitted to Shandong Provincial Public Health Clinical Centre from June 2021 to June 2023 were selected and divided into the control group and the study group(TBP with pleural fibrosis)according to whether they had combined pleural fibrosis,and were divided into mild,moderate,and severe pulmonary dysfunction groups according to their lung function.Results The levels of serum Nrf2,LXA4 and TGF-β,and pleural thickness in the study group were significantly higher than those in the control group(P<0.05),and the forced expiratory volume in one second(FEV1),forced vital capcacity(FVC)and FEV1/FVC were significantly lower than those in the control group(P<0.05).The serum levels of Nrf2,LXA4,TGF-β,and pleural thickness in the mild,moderate,and severe pulmonary dysfunction groups increased sequentially(P<0.05).Pearson correlation analysis showed that serum Nrf2,LXA4,and TGF-β levels were all correlated with FEV1,FVC,and FEV1/FVC,and pleural thickness(P<0.05).Multivariate logistic regression analysis showed that Nrf2,LXA4,and TGF-βlevels were the risk factors affecting TBP with pleural fibrosis(P<0.05).Receiver operating characteristic curve(ROC curve)analysis showed that the area under the curve(AUC)of the combined diagnosis of TBP with pleural fibrosis by Nrf2,LXA4,and TGF-βwas 0.934,and the combination of the three was superior to their respective individual diagnosis(all P<0.05).Conclusion The levels of serum Nrf2,LXA4,and TGF-β are significantly elevated in TBP patients,which is related to lung function and pleural thickness.Combined detection can improve the diagnostic value of TBP with pleural fibrosis.

关 键 词：核因子E2相关因子2 脂氧素A4 转化生长因子-Β 结核性胸膜炎 相关性 

分 类 号：R521.7[医药卫生—内科学]