老年女性患者中HPV基因型的分布特征及意义  

Distribution characteristics and significance of human papillomavirus genotype in elderly female patients

作　　者：邹玉凤[1] 李铤[2] 赵月鸣 张雪莹[3] 武艳[1] ZOU Yufeng;LI Ting;ZHAO Yueming;ZHANG Xueying;WU Yan(Department of Pathology,Jilin Cancer Hospital,Changchun 130012,China;Department of Laboratory,Jilin Cancer Hospital,Changchun 130012,China;The Third Department of Internal Medicine,Jilin Cancer Hospital,Changchun 130012,China)

机构地区：[1]吉林省肿瘤医院病理科,长春130012 [2]吉林省肿瘤医院检验科,长春130012 [3]吉林省肿瘤医院肿瘤内三科,长春130012

出　　处：《长春中医药大学学报》2024年第12期1397-1401,共5页Journal of Changchun University of Chinese Medicine

基　　金：吉林省科学技术厅重点研发项目(20240304051SF)。

摘　　要：目的分析老年女性患者中人乳头瘤病毒(HPV)基因型分布特征,为老年女性宫颈癌筛查、防治及接种疫苗提供理论依据。方法搜集2019年7月-2023年2月就诊的7716例女性患者,全部进行HPV检查,选择其中6722例60岁以下女性患者作为对照组,994例60岁及以上女性患者作为老年组。回顾分析其HPV导流杂交法检测结果,观察HPV感染检出情况和在不同年龄段感染分布特点,以及HPV阳性患者中高、低危分型占比情况。结果老年患者中HPV总阳性率为30.28%,单一感染阳性率为22.23%,多重感染阳性率为8.05%;对照组总阳性率为22.99%,单一感染阳性率为18.68%,多重感染阳性率为4.31%,差异具有统计学意义(P<0.01)。HPV感染阳性率最低的年龄段为75~79岁,阳性率为12.50%,60~64岁年龄段阳性率最高,为33.79%;各年龄段以单一感染为主,75~79岁HPV阳性率最低,为10%,60~64岁HPV感染阳性率最高,为24.56%。对照组和老年组患者低危型HPV81(CP8304)型检出率均最高,HPV11型检出率均最低;老年组和对照组高危HPV前5种分别是HPV16,HPV52,HPV58,HPV53,HPV51,均以单一感染为主。其中老年组各个年龄段感染率最高的是HPV16。结论在老年女性患者中,HPV阳性率比年轻女性患者高,且以单一、高危型感染为主,60~64岁年龄段HPV感染阳性率最高;高危型检出率最高前5种为HPV16、HPV52、HPV58、HPV53、HPV51。Objective To analyze the distribution characteristics of human papillomavirus(HPV)genotype in elderly female patients,and provide theoretical basis for detection,prevention and HPV vaccination of cervical cancer in elderly women.Methods 7716 female patients who visited Jilin Cancer Hospital from July 2019 to February 2023 were collected for HPV testing.Among them,6722 female patients under the age of 60 were selected as the control group,and 994 female patients aged 60 and above were selected as the elderly group.The detection results of HPV using flow-through hybridization method were analysed retrospectively.The detection of HPV infection and the distribution characteristics of infection in different age groups,as well as the proportion of high-risk and low-risk subtypes in HPV positive patients,were observed.Results The total positive rate of elderly patients was 30.28%,with a single infection positive rate of 22.23%and a multiple infection positive rate of 8.05%.The total positive rate of the control group was 22.99%,with a single infection positive rate of 18.68%and a multiple infection positive rate of 4.31%.There was statistically significant difference(P<0.01).The age group with the lowest HPV infection positive rate was 75-79 years old,with a positive rate of 12.50%,while the age group with the highest positive rate was 60-64 years old,with a positive rate of 33.79%.Single infection was predominant in all age groups,with the lowest HPV positive rate of 10%among individuals aged 75-79 years old,and the highest HPV positive rate of 24.56%among individuals aged 60-64 years.The detection rate of low-risk HPV81(CP8304)type was the highest in the control group and the elderly group,and the detection rate of HPV11 type was the lowest in both groups.The top five high-risk HPV types in the elderly group and the control group were HPV16,HPV52,HPV58,HPV53,and HPV51,all of which were predominantly monoinfections.The highest infection rate among all age groups in the elderly group was HPV16.Conclusion Among elderly f

关 键 词：人乳头瘤病毒 宫颈癌 基因型 老年 

分 类 号：R752.9[医药卫生—皮肤病学与性病学]