急性主动脉夹层患者凝血功能围术期的评价管理研究进展  

Research progress in perioperative evaluation and management of coagulation function in patients with acute aortic dissection

作　　者：潘晨宇[1] 颜文[1] 贯佳莹 马志伟 路畅[1] PAN Chenyu;YAN Wen;GUAN Jiaying;MA Zhiwei;LU Chang(Department of Anesthesia,The Second Hospital of Jilin University,Changchun 130041,China;Gastroenterology and Digestive Endoscopy Center,the Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院麻醉科,长春130041 [2]吉林大学第二医院胃肠内科及消化内镜中心,长春130041

出　　处：《长春中医药大学学报》2024年第12期1402-1405,共4页Journal of Changchun University of Chinese Medicine

基　　金：吉林省教育厅“十三五”科学技术项目(JJKH20211180KJ)。

摘　　要：急性主动脉夹层(AAD)是一种心血管系统危重疾病,因其进展迅速,症状致命的特点,在临床中受到重点关注。诸多研究发现,AAD患者凝血功能变化贯穿于疾病发生发展到转归全程。现通过归纳对比不同术式治疗AAD患者对其凝血功能影响,发现开放手术较腔内手术凝血功能变化更明显,并进一步总结出血小板、D-二聚体、凝血敏感蛋白以及纤维蛋白酶原可能是评价管理其术后凝血功能的生物标志物,旨在为制定合理有效的治疗方案提供参考依据。Acute aortic dissection(AAD)is a critical disease of the cardiovascular system that has received key attention in clinical practice because of its rapid progression and fatal symptoms.Many studies have found that changes in the coagulation function of AAD patients run through the entire process of the disease occurrence,development,and prognosis.By summarizing and comparing the effects of different surgical procedures on the coagulation function of AAD patients,it is found that open surgery results in more significant changes in coagulation function compared with endoluminal surgery.Furthermore,it is concluded that platelets,D-dimer,coagulation-sensitive proteins,andfibrinogen may be the biomarkers for evaluating and managing postoperative coagulation function of AAD patients,aiming to provide a certain reference for formulating a reasonable and effective therapeutic plan.

关 键 词：急性主动脉夹层 凝血因子 凝血功能 

分 类 号：R654.3[医药卫生—外科学]