足细胞基因与激素抵抗性肾病综合征的研究进展  

Research progress in podocyte gene and steroid-resistant nephrotic syndrome

作　　者：庞洁雅 陈连华[1] PANG Jieya;CHEN Lianhua(Huai'an First Hospital Affiliated to Nanjing Medical University,Huai'an 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院,江苏淮安223300

出　　处：《长春中医药大学学报》2024年第12期1412-1417,共6页Journal of Changchun University of Chinese Medicine

基　　金：江苏省卫生健康科研课题(H2020091)。

摘　　要：激素抵抗性肾病综合征(SRNS)是一种常见的肾脏疾病,通过疾病的发展,最终进展为肾脏终末期,严重威胁患者的生命安全。近年来,足细胞基因成为临床广泛关注的重点,考虑可能是SRNS主要致病机制。鉴于此,结合国内外研究文献,旨在综述足细胞基因与SRNS的研究进展。结合国内外研究发现,足细胞裂孔隔膜基因、足细胞骨架基因、足细胞线粒体蛋白基因及足细胞核蛋白基因的突变与足细胞功能受损及肾小球功能障碍有关,并最终导致包括SRNS等多种肾脏疾病,但这一领域的研究仍在不断深入中。因此,探索足细胞基因与SRNS之间的复杂关系,有助于临床更深入地理解SRNS的具体发病机制,并为制定更为精准和有效的治疗方案提供科学依据。Hormone-resistant nephrotic syndrome(SRNS)is a common renal disease.Through the development of the disease,it eventually progresses to the end stage of kidney,which seriously threatens the life safety of patients.In recent years,podocyte gene has become the focus of clinical attention,and consideration may be the main pathogenic mechanism of SRNS.In view of this,combined with the research literature at home and abroad,this paper aims to review the research progress of podocyte genes and SRNS.Through the combination of domestic and foreign research,it has been found that mutations in podocyte septal membrane genes,podocyte cytoskeleton genes,podocyte mitochondrial protein genes,and podocyte nuclear protein genes are associated with impaired podocyte function and glomerular dysfunction,ultimately leading to various kidney diseases including SRNS.However,research in this field is still ongoing.Therefore,exploring the complex relationship between podocyte genes and SRNS can help clinical doctors better understand the specific pathogenesis of SRNS and provide scientific basis for developing more precise and effective treatment plans.

关 键 词：足细胞基因 激素抵抗性肾病综合征 研究进展 

分 类 号：R692[医药卫生—泌尿科学]