佩索利单抗治疗急性泛发性脓疱型银屑病二例并文献复习  

Acute generalized pustular psoriasis treated with spesolimab:two cases report and literature review

作　　者：张猛 孙悦鑫 李志瑜[1] 包军[1] 周映[1] ZHANG Meng;SUN Yuexin;LI Zhiyu;BAO Jun;ZHOU Ying(Department of Dermatology,Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院皮肤科,江苏南京210008

出　　处：《中国麻风皮肤病杂志》2025年第1期37-42,共6页China Journal of Leprosy and Skin Diseases

基　　金：南京中医药大学自然科学基金项目(编号:XZR2020056)。

摘　　要：报道佩索利单抗治疗2例急性泛发性脓疱型银屑病(GPP)的疗效。2例患者均为男性,均有寻常型银屑病病史,均治疗1次(900 mg)。治疗前24 h的GPP医师总体评估(GPPGA)脓疱评分均为4,GPP皮损面积和严重程度指数(GPPASI)评分分别为48.0和59.3。2例患者治疗后48 h GPPGA脓疱单项评分均0,GPPASI评分改善率为91.04%和89.21%。治疗过程中,2例患者的实验室指标如白细胞计数、中性粒细胞计数及比例、C反应蛋白均在应用佩索利单抗后48 h内逐步回归或接近正常水平,且观察1周无反复,体温在给药后24 h内恢复正常且无反复。We report two patients with acute generalized pustular psoriasis(GPP)treated with spesolimab of a single 900 mg intravenous dose.Both patients were male and had a history of psoriasis vulgaris.The pretreatment generalized pustular psoriasis physician's general assessment(GPPGA)score was 4 in both patients.The scores of generalized pustular psoriasis area and severity index(GPPASI)were 48.0 and 59.3,respectively.The GPPGA pustular score of both were 0 at 48 hours after treatment,and the improvement rates of GPPASI were 91.04%and 89.21%,respectively.Laboratory parameters including white blood cell count,neutrophil count,neutrophil ratio,and C-reactive protein returned to or near normal levels within 48 hours after the application of spesolimab,and there was no recurrence during the 1-week observation.Body temperature returned to normal within 24 hours after the administration of spesolimab without recurrence.

关 键 词：急性泛发性脓疱型银屑病 佩索利单抗 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]