超说明书应用阿普米司特治疗皮肤病进展  

Off-label uses of apremilast in dermatology

作　　者：李慧杰 焦雨竹 杨青 LI Huijie;JIAO Yuzhu;YANG Qing(Hospital for Skin Diseases,Shandong First Medical University,Jinan 250022,China;Shandong Provincial Institute of Dermatology and Venereology,Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院,山东济南250022 [2]山东省皮肤病性病防治研究所,山东济南250022

出　　处：《中国麻风皮肤病杂志》2025年第1期79-83,共5页China Journal of Leprosy and Skin Diseases

基　　金：山东省医药卫生科技发展计划项目(编号:202004120466);济南市临床医学科技创新计划(编号:202134012)。

摘　　要：阿普米司特是一种通过抑制磷酸二酯酶-4(PDE4)发挥作用的小分子药物,已在我国获批治疗斑块状银屑病。笔者以“apremilast”为关键词对PubMed数据库进行检索,并对银屑病关节炎、白塞病、白癜风、斑秃、化脓性汗腺炎和特应性皮炎的随机对照试验数据,以及该药应用于特应性皮炎、Hailey-Hailey病、化脓性汗腺炎、皮肌炎、系统性硬化症、慢性光化性皮炎及坏疽性脓皮病等疾病的病例报道进行了综述,为该药在皮肤科的应用提供借鉴。Apremilast,a small molecule that acts by inhibition of the phosphodiesterase-4 enzyme,has been approved for the management of plaque psoriasis in China.Utilizing‘apremilast’as a keyword in the title,the PubMed database was searched for randomized controlled trial data on psoriatic arthritis,Beh et s disease,vitiligo,alopecia and hidramatitis,and case reports of atopic dermatitis,Hailey-Hailey disease,hidradenitis suppurativata,dermatomyositis,systemic sclerosis,chronic actinic dermatitis and pyoderma gangrenosum treated with apremilast.Then we summarized the retrieved literature offering a reference for clinical practice.

关 键 词：阿普米司特 皮肤疾病 超说明书应用 

分 类 号：R751[医药卫生—皮肤病学与性病学]