女性雄激素性秃发患者614例家族史和血清双氢睾酮水平与其发病的相关性分析  

Correlations of the onset of androgenic alopecia with family history and serum dihydrotestosterone levels in 614 female patients

作　　者：汪丽俐 杨斌[2] 罗颖 Wang Lili;Yang Bin;Luo Ying(Guangdong Provincial People′s Hospital′s Nanhai Hospital,Foshan 528251,Guangdong,China;Dermatology Hospital of Southern Medical University,Guangzhou 510091,China)

机构地区：[1]广东省人民医院南海医院,佛山528251 [2]南方医科大学附属皮肤病医院,广州510091

出　　处：《中华皮肤科杂志》2024年第12期1127-1129,共3页Chinese Journal of Dermatology

摘　　要：目的分析女性雄激素性秃发(FAGA)患者家族史、血清双氢睾酮(DHT)水平对其发病年龄的影响。方法回顾性分析2019年11月至2021年1月南方医科大学皮肤病医院确诊符合条件的FAGA的初诊患者614例及健康对照93例,对FAGA患者家族史、血清DHT水平、发病年龄和病程进行统计学分析,比较FAGA患者血清DHT水平与对照组的差异。结果614例患者年龄(27.71±6.11)岁,发病年龄(25.25±6.12)岁,病程中位数为2.46年。其中家族史阳性者231例(37.62%);DHT水平升高者192例(31.6%)。20~30岁患者DHT水平最高[310.19(238.98,415.77)pg/ml],其次分别为31~40岁患者[273.24(193.85,357.53)pg/ml]和41~50岁患者[216.61(166.92,289.98)pg/ml],差异有统计学意义(P<0.05)。20~30岁患者DHT水平高于对照组[298.55(218.19,325.89)pg/ml,Z=2.39,P=0.017],31~40岁和41~50岁患者与同年龄对照组DHT水平差异无统计学意义(P>0.05)。DHT升高组患者发病年龄和就诊年龄均低于DHT正常组(均P<0.001),两组病程差异无统计学意义(P=0.350)。有家族史的患者发病年龄[(24.61±5.90)岁]低于无家族史的患者[(25.64±6.22)岁;t=2.02,P=0.044],有无家族史的患者间DHT水平差异无统计学意义(Z=-0.52,P=0.605)。结论20~30岁FAGA患者血清DHT水平较健康人高,随着年龄增长可恢复到正常水平,未发现家族史与DHT水平有相关性,有家族史的患者发病年龄早于无家族史的患者。Objective To analyze the effect of family history of female androgenetic alopecia(FAGA)and serum dihydrotestosterone(DHT)levels on the age at onset.Methods A retrospective analysis was conducted on 614 eligible patients newly diagnosed with confirmed FAGA at the Dermatology Hospital of Southern Medical University from November 2019 to January 2021,and 93 healthy controls were collected during the same period.Data on FAGA patients′family history,serum DHT levels,age at onset,and duration of disease were analyzed,and differences in serum DHT levels were analyzed between the FAGA group and the control group.Results Among the 614 patients,the ages were 27.71±6.11 years,the ages at onset were 25.25±6.12 years,and the median duration of disease was 2.46 years;there were 231 patients(37.62%)with a positive family history and 192(31.6%)with elevated DHT levels.Patients aged 20-30 years exhibited the highest DHT levels(310.19[238.98,415.77]pg/ml),followed by those aged 31-40 years(273.24[193.85,357.53]pg/ml)and those aged 41-50 years(216.61[166.92,289.98]pg/ml),and the difference was statistically significant(P<0.05).DHT levels were significantly higher in the patients aged 20-30 years than in the controls of the same age(298.55[218.19,325.89]pg/ml,Z=2.39,P=0.017),and no significant differences in DHT levels were observed between the patients aged 31-40 years and their controls of the same age,nor between the patients aged 41-50 years and their controls of the same age(both P>0.05).The age at onset and age at consultation were significantly lower in the elevated DHT group than in the normal DHT group(both P<0.001),while the difference in disease duration was not statistically significant between the two groups(P=0.350).The age at onset was significantly lower in the patients with a family history(24.61±5.90 years)than in those without(25.64±6.22 years;t=2.02,P=0.044),and the difference in DHT levels was not statistically significant between the two groups(Z=-0.52,P=0.605).Conclusions The serum DHT levels were higher

关 键 词：秃发 女性 雄激素性秃发 双氢睾酮 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]