中蒙药提取物治疗肝纤维化的研究进展  

Research progress in the treatment of liver fibrosis with extracts of traditional Chinese and Mongolian medicine

作　　者：颜羽昕 陈玥 高玉杰 朱磊 易仁平 YAN Yuxin;CHEN Yue;GAO Yujie;ZHU Lei;YI Renping(Department of Pharmacy,the People’s Hospital,Henan of Yizheng,Jiangsu,Yizheng 211400,China)

机构地区：[1]江苏省仪征市人民医院药剂科,江苏仪征211400

出　　处：《中国医药科学》2024年第22期26-28,59,共4页China Medicine And Pharmacy

基　　金：江苏省药学会-奥赛康医院药学科研基金项目(A202350)。

摘　　要：肝纤维化(HF)是由大多数病毒性或代谢性肝损伤引起的,是肝损伤发生率较高的病理特征之一。目前,治疗HF的药物种类繁多。然而,西药往往只针对单个基因/蛋白质并诱发许多不良反应,中蒙药的作用机制和有效成分大多不明确。但由中蒙药提取出的天然化合产物具有结构多样、来源广泛等特点,在抗HF方面具有独特的优势和巨大的潜力。经鉴定,由中蒙药中提取出的有效抗HF成分一般可分为黄酮类、酚类、萜类和生物碱类。抗HF的作用机制包括抑制炎症、抗脂质过氧化损伤、抑制肝星状细胞的活化和增殖、调节细胞外基质的合成和降解。本文综述近年来中蒙药提取物治疗HF的研究进展,以期为今后中蒙药提取物治疗HF的研究提供新方向。Hepatic fibrosis(HF)is caused by most viral or metabolic liver injuries,and it is one of the pathological features with high incidence of liver injuries.At present,there are many kinds of drugs to treat HF.However,western medicine often only targets at a single gene/protein and induces many adverse reactions.The mechanism of action and effective components of traditional Chinese and Mongolian medicines are mostly unclear.However,the natural compound products extracted from Chinese and Mongolian medicines have the characteristics of diverse structures and wide sources,and have unique advantages and great potential in anti-HF.After identification,the effective anti-HF components extracted from Chinese and Mongolian medicines can generally be divided into flavonoids,phenols,terpenoids and alkaloids.The mechanism of anti-HF includes inhibiting inflammation,inhibiting lipid peroxidation damage,inhibiting the activation and proliferation of hepatic stellate cells,and regulating the synthesis and degradation of extracellular matrix.This paper summarizes the research progress of traditional Chinese and Mongolian medicine extracts in treating HF in recent years,in order to provide a new direction for future research on traditional Chinese and Mongolian medicine extracts in treating HF.

关 键 词：肝纤维化 中蒙药提取物 生物碱 黄酮 

分 类 号：R29[医药卫生—民族医学]