基于迷走神经-肾上腺抗炎通路探讨针刺治疗脓毒症的研究进展  

Research progress of acupuncture treatment of sepsis based on vagus nerve-adrenal anti-inflammatory pathway

作　　者：杨楠 赵文辉 徐晖[2] YANG Nan;ZHAO Wenhui;XU Hui(Jiangxi University of Chinese Medicine,Jiangxi,Nanchang 330006,China;Department of Critical Care Medicine,Affiliated Hospital of Jiangxi University of Chinese Medicine,Jiangxi,Nanchang 330006,China)

机构地区：[1]江西中医药大学,江西南昌330006 [2]江西中医药大学附属医院重症医学科,江西南昌330006

出　　处：《中国医药科学》2024年第22期29-33,共5页China Medicine And Pharmacy

基　　金：江西省中医药管理局科技计划(2023B0572)。

摘　　要：脓毒症是因感染所致的一种临床上常见的急危重症疾病,因其发病快、预后差、病死率高的特点受到国内外临床医生的广泛关注。作为传统中医治疗手段之一,针刺治疗在各类疾病中被广泛应用,近年来针刺发挥抗炎作用和提高免疫功能治疗脓毒症得到众多研究的证实。本文回顾、总结近年来针刺治疗脓毒症的作用机制,探讨分析针刺治疗激活迷走神经-肾上腺轴起到抗炎作用并治疗脓毒症的作用机制,分析刺激迷走神经通过下丘脑-垂体-肾上腺轴使肾上腺分泌皮质醇以及儿茶酚胺类抗炎物质在脓毒症治疗中的作用,以期从迷走神经-肾上腺抗炎通路出发为针刺治疗脓毒症的机制研究以及针刺通过自主神经抗炎治疗脓毒症的研究提供一个新的视角。Sepsis is a common acute and critical disease caused by infection,which has attracted wide attention of clinicians at home and abroad because of its rapid onset,poor prognosis and high mortality.As a traditional Chinese medicine treatment,acupuncture is widely used in various diseases.In recent years,acupuncture has played an anti-inflammatory role and improved immune function to treat sepsis,which has been confirmed by many studies.The mechanism of acupuncture in the treatment of sepsis in recent years is reviewed and summarized in this paper,the mechanism of acupuncture in activating vagus nerve-adrenal axis to play an anti-inflammatory role and treat sepsis is discussed and analyzed,and the role of stimulating vagus nerve through hypothalamus-pituitary-adrenal axis to make adrenal gland secrete cortisol and catecholamine anti-inflammatory substances in the treatment of sepsis is investigated,so as to provide a new perspective for the study of acupuncture in the treatment of sepsis from the perspective of vagus nerve-adrenal anti-inflammatory pathway and acupuncture in the treatment of sepsis through autonomic nerve anti-inflammation.

关 键 词：针刺 脓毒症 迷走神经-肾上腺轴 机制研究 

分 类 号：R246[医药卫生—针灸推拿学]