骨关节炎中细胞因子、骨密度及骨标志物致病因素的研究进展  

Research progress of pathogenic factors of cytokines,bone mineral density and bone markers in osteoarthritis

作　　者：邢惠凯 李芳[1] 薛丽巾[1] 刘玉芳[1] 郑丽[1] XING Huikai;LI Fang;XUE Lijin;LIU Yufang;ZHENG Li(Department of Rheumatology and Immunology,the Second Hospital of Shanxi Medical University,Shanxi,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院风湿免疫科,山西太原030001

出　　处：《中国医药科学》2024年第22期34-38,共5页China Medicine And Pharmacy

基　　金：山西华晋骨科公益基金项目(20210401)。

摘　　要：骨关节炎(OA)是关节的一种慢性退行性疾病,涉及关节软骨及其周围组织,其主要临床表现为关节肿痛、僵硬和活动受限,通常进展缓慢,但最终可导致关节功能障碍并伴有残疾,严重影响患者的生活质量。目前针对OA的治疗手段主要为缓解疼痛,不能完全阻止关节组织的损伤或OA的进展。性别、年龄、体重指数、细胞因子、骨密度及骨标志物都参与了OA的发病,且多种致病因素间相互影响,共同导致疾病的发展。近年来,关于病因和发病机制的探索成为研究OA的主要方向。因此,本文将对细胞因子、骨密度及骨标志物在OA发病机制方面的研究进展做一综述,希望为OA的早期诊断及治疗提供新的思路。Osteoarthritis(OA)is a chronic degenerative disease of joints,involving articular cartilage and its surrounding tissues.Its main clinical manifestations are joint swelling and pain,stiffness and limited activity.It usually progresses slowly,but it can eventually lead to joint dysfunction with disability,which seriously impacts the quality of life of patients.At present,the treatment method for OA is mainly to relieve pain,which can not completely prevent the damage of joint tissue or the progress of OA.Gender,age,body mass index,cytokines,bone mineral density and bone markers are all involved in the pathogenesis of OA,and many pathogenic factors interact with each other to jointly lead to the development of the disease.In recent years,the investigation of etiology and pathogenesis has become the main direction of studying OA.Therefore,this article will review the research progress of cytokines,bone mineral density and bone markers in the pathogenesis of OA,hoping to provide new ideas for the early diagnosis and treatment of OA.

关 键 词：骨关节炎 细胞因子 骨密度 25羟维生素D 骨钙素 降钙素 

分 类 号：R246.9[医药卫生—针灸推拿学]