血清VEGF、Ang-2与急性心肌梗死患者PCI治疗预后的相关性  

Correlation between serum VEGF,Ang-2 and the prognosis of patients with acute myocardial infarction underwent PCI treatment

作　　者：黄丽君 郝雪峰[1] 赵德全 Huang Lijun;Hao Xuefeng;Zhao Dequan(Department of Cardiology,the Third People's Hospital of Zhengzhou,Zhengzhou,Henan 450000,China.)

机构地区：[1]郑州市第三人民医院心内科,河南郑州450000

出　　处：《齐齐哈尔医学院学报》2024年第22期2137-2141,共5页Journal of Qiqihar Medical University

摘　　要：目的探讨血清血管内皮生长因子(VEGF)、血管生成素2(Ang-2)与急性心肌梗死患者经皮冠状动脉介入术(PCI)预后的相关性。方法回顾性分析2021年1月—2022年12月本院100名健康体检者的资料,纳入对照组;采集同期于医院接受PCI治疗的100例急性心肌梗死患者资料,纳入观察组。研究对象疾病资料或体检资料、检查结果等资料均保存完整。整理研究对象资料,记录入院时的血清VEGF、Ang-2水平,记录急性心肌梗死患者PCI后不良心血管事件(MACE)发生情况,将患者分为预后良好组(n=76)和预后不良组(n=24),比较两组基线资料,重点探讨血清VEGF、Ang-2与急性心肌梗死患者PCI后预后的相关性。结果相较于对照组,观察组血清VEGF、Ang-2水平均较高(P<0.05)。预后良好组与预后不良组患者在性别、年龄、体质量指数等方面对比,差异无统计学意义(>0.05),但预后不良组Gensini评分>30分占比以及入院当天的血清VEGF、Ang-2水平均高于预后良好组(P<0.05)。经限制性立方样条分析结果显示,血清VEGF、Ang-2水平与急性心肌梗死患者PCI后预后不良的关联强度呈线性剂量反应关系(P<0.05);当血清VEGF、Ang-2阈值分别取135.79 ng/L、19.23 ng/ml时,急性心肌梗死患者PCI治疗预后不良风险随血清VEGF、Ang-2水平升高而增加。血清VEGF、Ang-2水平均高表达时,急性心肌梗死患者PCI治疗预后不良是血清VEGF、Ang-2均低表达时的8.333倍,是其他未知因子(OR=1)的5.497倍(RERI=5.497),协同效应为二者单独存在产生效应之和的3.994倍(SI=3.994)。结论血清VEGF、Ang-2与急性心肌梗死患者PCI治疗预后密切相关,患者入院时表现出血清VEGF、Ang-2异常表达上调,可能提示不良预后高风险,应引起重视。Objective To explore the correlation between serum vascular endothelial growth factor(VEGF),angiopoietin-2(Ang-2)and the prognosis of patients with acute myocardial infarction who underwent percutaneous coronary intervention(PCI).Methods Retrospective analysis was conducted to collect data from 100 healthy individuals who underwent physical examinations in our hospital from January 2021 to December 2022,and they were included in the control group.Data from 100 patients with acute myocardial infarction who received PCI treatment in the same hospital during the same period were collected and included in the observation group.The disease data,physical examination data,and examination results of the research subjects were all kept intact.The data of the subjects were collected,the serum levels of VEGF and Ang-2 at admission were recorded,and the occurrence of adverse cardiovascular events(MACE)after PCI in patients with acute myocardial infarction was recorded.The patients were divided into a good prognosis group(n=76)and a poor prognosis group(n=24).The baseline data of the two groups were compared,and the correlation between serum VEGF and Ang-2 and the prognosis of patients with acute myocardial infarction after PCI was discussed.Results Compared with the control group,the observation group had higher levels of serum VEGF and Ang-2(P<0.05).There was no statistically significant difference in gender,age,and body mass index between the patients with good prognosis and those with poor prognosis(P>0.05),but the proportion of patients with a Gensini score greater than 30 and the serum VEGF and Ang-2 levels on the day of admission in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The results of restricted cubic spline analysis showed a linear dose-response relationship between serum VEGF and Ang-2 levels and poor prognosis after PCI in patients with acute myocardial infarction(P<0.05).When the serum VEGF and Ang-2 thresholds were set at 135.79 ng/L and 19.23 ng/mL,respectively,the ri

关 键 词：急性心肌梗死 血管成形术 血管内皮生长因子 血管生成素2 预后 

分 类 号：R541.4[医药卫生—心血管疾病]