丹参酮ⅡA磺酸钠注射液联合负压引流治疗腹部难愈性手术切口的疗效观察及对机体心率变异性的影响  

Observation on efficacy of sodium tanshinoneⅡA sulfonate injection combined with negative pressure drainage in treatment of abdominal refractory surgical incision and its influence on heart rate variability

作　　者：李旻昊 袁梅 巢琳[1] Li Minmin;Yuan Mei;Chao Lin(Department of General Surgery,the Second People's Hospital of Wuxi,Wuxi,Jiangsu 214000,China;Function Department,Wuxi Fifth People's Hospital,Wuxi,Jiangsu 214000,China)

机构地区：[1]无锡市第二人民医院普通外科,江苏无锡214000 [2]无锡市第五人民医院功能科

出　　处：《齐齐哈尔医学院学报》2024年第22期2142-2145,共4页Journal of Qiqihar Medical University

摘　　要：目的观察丹参酮ⅡA磺酸钠注射液并负压引流治疗腹部难愈性手术切口的临床疗效,并探讨其对机体心率变异性的影响。方法选择2020年5月—2024年5月本院收治的手术后出现腹部切口愈合不良的90例患者作为研究对象,随机分为对照组和观察组两组,每组各45例。两组均采用局部负压引流治疗,观察组在此基础上加用丹参酮ⅡA磺酸钠注射液冲洗治疗。比较两组患者平均切口愈合时间及住院时间来评估临床疗效,比较两组患者治疗前、治疗7 d后的血清C反应蛋白(CRP)、白细胞介素-6(IL-6)数值变化,动态心电图检测pNN50、SDNN、rMSSD来评估患者的心率变异性(HRV)情况。结果观察组切口愈合时间为(11.68±1.33)d,低于对照组的(17.35±1.59)d,差异有统计学意义(P<0.05)。两组患者治疗后的炎性因子CRP、IL-6数值明显低于治疗前,且以观察组降低更为明显(P<0.05)。两组患者治疗后心率变异性指标pNN50、SDNN、rMSSD较治疗前均升高,以观察组升高更为明显,差异具有统计学意义(P<0.05)。结论术后切口愈合不良患者常合并心率变异性减低,应用丹参酮ⅡA磺酸钠注射液并负压引流治疗能够提高显著机体的心率变异性,故推测丹参酮ⅡA磺酸钠注射液促进手术切口愈合,除了与其参与的抗炎作用外,还可能与调节机体的心率变异性有关。Objective To observe the clinical effect of sodium tanshinoneⅡA sulfonate injection combined with negative pressure drainage in the treatment of abdominal refractory surgical incision,and to explore its effect on body heart rate variability.Methods A total of 90 patients with poor abdominal incision healing after surgery,admitted to our hospital from May 2020 to May 2024,were selected as study subjects and randomly divided into a control group and an observation group,with 45 patients in each group.Both groups were treated with local negative pressure drainage.The difference was that the observation group was treated with sodium tanshinoneⅡA sulfonate injection in addition to the control group's treatment.The average incision healing time and hospital stay were compared between the two groups to evaluate clinical efficacy,and the changes in serum C-reactive protein(CRP)and interleukin-6(IL-6)levels before treatment and 7 days after treatment were compared between the two groups.Heart rate variability(HRV)was assessed by 24-hour dynamic electrocardiogram,measuring pNN50,SDNN,and rMSSD.Results The wound healing time in the observation group was(11.68±1.33)days,which was lower than that in the control group(17.35±1.59)days;the difference was statistically significant(P<0.05).The levels of inflammatory factors CRP and IL-6 in both groups after treatment were significantly lower than before treatment,with the observation group showing a more pronounced decrease,and the difference was statistically significant(P<0.05).The HRV indices pNN50,SDNN,and rMSSD in both groups were significantly higher after treatment than before treatment,with the observation group showing a more significant increase,and the difference was statistically significant(P<0.05).Conclusions Patients with poor wound healing after surgery often have decreased heart rate variability,and the application of sodium tanshinoneⅡA sulfonate injection combined with negative pressure drainage can significantly improve the body's heart rate variability

关 键 词：丹参酮ⅡA磺酸钠注射液 负压引流 难愈性手术切口 CRP IL-6 心率变异性。 

分 类 号：R632.9[医药卫生—外科学]