血清Aβ1-42、CXCL16、VILIP-1联合对帕金森病患者认知障碍的预测价值  

Predictive value of serum Aβ1-42,CXCL16 and VILIP-1 in combination for cognitive impairment in Parkinson's disease patients

作　　者：胡晓丹[1] 蒙云[1] 林泓宇 HU Xiaodan;MENG Yun;LIN Hongyu(Department of Neurology,Red Cross Hospital of Yulin City,Yulin 537000,Guangxi,China)

机构地区：[1]玉林市红十字会医院神经内科,玉林537000

出　　处：《医学研究与战创伤救治》2024年第10期1050-1054,共5页Journal of Medical Research & Combat Trauma Care

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180442)。

摘　　要：目的探究血清β淀粉样蛋白1-42(Aβ1-42)、趋化因子配体16(CXCL16)、视锥蛋白样蛋白1(VILIP-1)联合对帕金森病(PD)患者认知障碍的预测价值。方法选取2021年12月至2022年12月玉林市红十字会医院神经内科收治的81例PD患者为PD组。另选同期健康体检者(n=81)为对照组。再次根据PD患者MoCA评分分为认知正常组(≥26分,n=44)、认知障碍组(<26分,n=37)。采用ELISA测定血清Aβ1-42、CXCL16、VILIP-1表达水平;采用Logistic回归分析影响PD患者认知障碍的因素;采用受试者工作特征(ROC)曲线分析血清Aβ1-42、CXCL16、VILIP-1对PD患者认知障碍的预测价值。结果与对照组相比,PD组血清Aβ1-42表达水平显著降低(P<0.05),CXCL16、VILIP-1表达水平显著升高(P<0.05)。与认知正常组相比,认知障碍组血清Aβ1-42表达水平显著降低(P<0.05),CXCL16、VILIP-1表达水平显著升高(P<0.05)。多因素Logistic回归分析显示,Aβ1-42是影响PD患者认知障碍的保护因素(P<0.05),CXCL16、VILIP-1是影响PD患者认知障碍的危险因素(P<0.05)。ROC显示了血清Aβ1-42、CXCL16、VILIP-1三者联合预测PD患者发生认知障碍的AUC最高,其评估效能显著优于血清Aβ1-42、CXCL16、VILIP-1各自单独预测(Z三者联合-Aβ1-42=2.056、P=0.040,Z三者联合-CXCL16=2.716、P=0.007,Z三者联合-VILIP-1=2.394、P=0.017)。结论PD患者血清Aβ1-42表达水平显著降低,CXCL16、VILIP-1表达水平显著升高,三者联合可以更好地预测认知障碍的发生。Objective To explore the predictive value of serum amyloidβ-protein 1-42(Aβ1-42),CXC chemokine ligand 16(CXCL16),and visinin like protein 1(VILIP-1)in combination for cognitive impairment in patients with Parkinson's disease(PD).Methods A total of 81 PD patients(n=81)admitted to the Neurology Department of Yulin Red Cross Hospital from December 2021 to December 2022 were selected as the PD group,and 81 healthy individuals(n=81)undergoing physical examinations during the same period were selected as the control group.The PD patients were further divided into a normal cognitive group(≥26 points,n=44)and a cognitive impairment group(<26 points,n=37)based on the Montreal Cognitive Assessment(MoCA)scores.Serum levels of Aβ1-42,CXCL16 and VILIP-1 were determined by enzyme-linked immunosorbent assay(ELISA).The factors affecting cognitive impairment in PD patients were analyzed by logistic regression.The predictive value of serum Aβ1-42,CXCL16,and VILIP-1 for cognitive impairment in PD patients was analyzed by Receiver Operating Characteristic(ROC)curves.Results Compared to the control group,the PD group had significantly lower serum Aβ1-42 levels(P<0.05)and significantly higher levels of CXCL16 and VILIP-1(P<0.05).Compared to the normal cognitive group,the cognitive impairment group had significantly lower serum Aβ1-42 levels(P<0.05)and significantly higher levels of CXCL16 and VILIP-1(P<0.05).Multivariate logistic regression analysis showed that Aβ1-42 is a protective factor against cognitive impairment in PD patients(P<0.05),while CXCL16 and VILIP-1 are risk factors(P<0.05).ROC analysis showed that the combined prediction of serum Aβ1-42,CXCL16,and VILIP-1 had the highest AUC for predicting cognitive impairment in PD patients,significantly outperforming individual predictions by Aβ1-42,CXCL16,and VILIP-1(Z triple combination-Aβ1-42=2.056,P=0.040,Z triple combination-CXCL16=2.716,P=0.007,Z triple combination-VILIP-1=2.394,P=0.017).Conclusion Sserum levels of Aβ1-42 are significantly decreased,while CXCL16

关 键 词：β淀粉样蛋白1-42 趋化因子配体16 视锥蛋白样蛋白1 帕金森病 认知障碍 预测 

分 类 号：R749[医药卫生—神经病学与精神病学]