血小板膜仿生纳米递药系统在心血管疾病靶向治疗的研究进展  

Advances in platelet membrane bionic nanoparticle delivery system for targeted therapy of cardiovascular diseases

作　　者：马柯(综述) 麦筱莉(审校)[2] MA Ke;MAI Xiaoli(Department of Radiology,Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University,Nanjing 210008,Jiangsu,China;Department of Radiology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,Jiangsu,China)

机构地区：[1]徐州医科大学鼓楼临床学院医学影像科,南京210008 [2]南京大学医学院附属鼓楼医院医学影像科,南京210008

出　　处：《医学研究与战创伤救治》2024年第10期1098-1102,共5页Journal of Medical Research & Combat Trauma Care

基　　金：江苏省研究生科研与实践创新计划项目(SJCX23_1404);南京市医学科技发展重点项目(ZKX21023)。

摘　　要：基于仿生细胞膜的纳米颗粒递送系统在生物医学领域快速发展。血小板凭借其生理特性参与炎症调节、免疫防御、止血及血栓形成、肿瘤的生长及转移等过程。血小板膜包裹的纳米颗粒借助血小板的独特功能已经被广泛应用于各系统疾病。文章主要就血小板膜仿生纳米递药系统在心血管疾病靶向治疗中的研究进展进行综述。Nanoparticle delivery systems based on bionic functional membranes are rapidly developing in the biomedical field.Platelets,due to their physiological properties,are involved in inflammation regulation,immune defense,hemostasis and thrombosis,tumor growth and metastasis.Platelet membrane-coated nanoparticles have been widely used in various systemic diseases with the unique function of platelets.This paper mainly reviews the progress of platelet membrane bionic nanoparticle delivery system in the targeted therapy of cardiovascular diseases.

关 键 词：仿生纳米递药系统 细胞膜包裹纳米颗粒 血小板膜 心血管疾病 靶向治疗 

分 类 号：R541[医药卫生—心血管疾病] R543[医药卫生—内科学]