Spherical nucleic acids for biomedical applications  

作　　者：Chunxin Xia Hemei Cheng Xinwei Hou Yu Zhang Xinchi Zhou Qinglong Yan Shuting Cao 

机构地区：[1]Jiaxing Key Laboratory of Bio-semiconductor,Xiangfu Laboratory,Jiashan 314102,China [2]Nano-translational Medicine Research Center,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 314000,China [3]The Interdisciplinary Research Center,Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China

出　　处：《Advanced Sensor and Energy Materials》2024年第4期37-49,共13页先进传感器与能源材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2023YFA0915200);the National Natural Science Foundation of China(12305400,12105352);the Natural Science Foundation of Shanghai,China(22ZR1470600);the Xiangfu Lab Research Project(XF012022E0100).

摘　　要：Spherical nucleic acids(SNAs)are a 3D spherical nanostructure composed of highly oriented,dense layers of oligonucleotides conjugated to a hollow or solid core.This structure allows SNAs to show resistance to nuclease degradation,enter into nearly all cells without transfection agents and enable precise interactions with target molecules.Based on superior biological properties,SNAs can be tailored for diverse biological applications,rendering them a flexible and biosafe tool for biological applications as well as an enabling platform for therapy.In this review,we mainly discuss the structure and conjugation mode of SNAs and focus on recent advances in their applications,such as biomedical detection,imaging,and drug delivery.Finally,the remaining challenges and future directions of SNAs are also discussed and proposed.

关 键 词：Spherical nucleic acids Conjugation mode Biomedical detection IMAGING Drug delivery 

分 类 号：TF1[冶金工程—冶金物理化学]