Central depressant effects of Piper tuberculatum Jacq essential oil in mice  

作　　者：Valterlúcio dos Santos Sales Francisco Romero Cabral Emmily Petícia do Nascimento Sales Tatyelle Bezerra Carvalho Maria Haiele Nogueira Costa Victor Afonso Pereira de Oliveira Cristina Kelly de Souza Rodrigues Francisco Rodolpho Sobreira Dantas Nobrega de Figueiredo Daniel Souza Bezerra Gyllyandeson de Araújo Delmondes Henrique Douglas Melo Coutinho Jose Galberto Martins da Costa Irwin Rose Alencar de Menezes Cícero Francisco Bezerra Felipe Marta Regina Kerntopf 

机构地区：[1]Universidade Regional do Cariri,Departamento de Química Biol´ogica,Crato,Cear´a,Brazil [2]Universidade Federal de S˜ao Paulo-Departamento de Fisiologia,S˜ao Paulo,SP,Brazil [3]Faculdade de Ciˆencias M´edicas da Santa Casa de S˜ao Paulo,S˜ao Paulo,SP,Brazil [4]Universidade Federal da Paraíba,Departamento de Biologia Molecular,Jo˜ao Pessoa,Paraíba,Brazil

出　　处：《Food Bioscience》2022年第4期620-629,共10页食品生物科学（英文）

摘　　要：This study aims to investigate the toxicity and possible effects and mechanism of action of the essential oil obtained from the Piper tuberculatum Jacq.‘s fruit(EOPT)on the central nervous system(CNS)of mice.In the Hippocratic test,it was observed ambulation reduction,sedation,piloerection and mortality of 25%at the dose of 1000 mg/kg and 50%at the dose of 5000 mg/kg.The results found demonstrate that the EOPT is endowed with a possible depressant effect,and is characterized by a likely sedative(open field test),anxiolytic-like(elevated plus maze test),anticonvulsant(pentylenetetrazole-induced seizure test)and hypnotic action(pentobarbital-induced sleeping time).These effects may possibly occur due to the interaction between the monoterpenes,present in its essential oil,and the GABAergic pathway confirmed by reversion of the effects by flumazenil.Then,these results demonstrate the therapeutic potential and the validation of the ethnopharmacological use of this species in the treatment of disorders affecting the central nervous system.

关 键 词：Piper tuberculatum Jacq. Essential oil SEDATIVE Anxiolytic HYPNOTIC 

分 类 号：R96[医药卫生—药理学]