中高能回旋加速器制备^(68)Ge工艺模拟研究  

Process Simulation of ^(68)Ge Preparation by Medium-High Energy Cyclotrons

作　　者：李勇 官国英 安世忠[1] 王宇 赵鹏飞 赵云龙 LI Yong;GUAN Guoying;AN Shizhong;WANG Yu;ZHAO Pengfei;ZHAO Yunlong(China Institute of Atomic Energy,Beijing 102413,China)

机构地区：[1]中国原子能科学研究院,北京102413

出　　处：《同位素》2024年第6期540-548,共9页Journal of Isotopes

基　　金：国家重点研发计划(2021YFF0701900);国防科工局核能开发科研项目(BA040251223264)。

摘　　要：为利用中高能回旋加速器开展重要医用放射性同位素^(68)Ge的生产制备,本研究进行镓镍合金靶件制备及质量检验,靶件溶解,分析检测方法建立及^(68)Ge分离纯化工艺模拟条件优化。首先通过优化电沉积工艺条件,在铜靶托上制备镓镍合金靶件,利用ICP-MS建立分析检测方法,借助电化学阳极氧化方法完成镓镍合金靶件溶解工艺研究,利用Tulsimer CH-90螯合树脂和Sephadex G25凝胶树脂组合进行^(68)Ge分离纯化模拟工艺条件优化。结果表明,制备的镓镍合金靶件表面光滑平整,成分分布均匀,镓含量74.7%,镍含量25.3%,厚度179 mg/cm^(2),可用于30 MeV以上中高能质子辐照。建立的ICP-MS内标法可对锗和杂质元素进行准确定量检测。电化学法可简单、快速地溶解镓镍合金层,避免加热。螯合树脂和凝胶树脂组合分离纯化可得到高回收率,高纯度的含锗样品溶液。通过上述工艺模拟研究,建立了制靶、溶靶、分析检测和分离纯化工艺模拟流程,可为中高能回旋加速器制备^(68)Ge提供技术支持。This study focuses on the simulation of target preparation,dissolution,and separationpurification processes for the production of the vital medical radioactive isotope ^(68)Ge using mediumhigh energy cyclotrons.It encompasses the preparation and quality inspection of gallium-nickel alloy targets,target dissolution,the establishment of analytical detection methods,and the optimization of simulation conditions for the separation and purification of ^(68)Ge.Initially,gallium-nickel alloy targets were prepared on copper backing plates by optimizing the electrodeposition process conditions.Analytical detection methods were then established using inductively coupled plasma mass spectrometry(ICP-MS).Subsequently,the dissolution process of the gallium-nickel alloy targets was studied using an electrochemical anodic oxidation method.Finally,the combined use of Tulsimer CH-90 chelating resin and Sephadex G25 gel resin was employed to optimize the simulation conditions for the separation and purification of ^(68)Ge,completing the process simulation study.The results indicate that the prepared gallium-nickel alloy targets have a smooth and flat surface with a uniform composition distribution,containing 74.7% gallium and 25.3% nickel,and have a thickness of 179 mg/cm^(2),suitable for medium-high energy proton irradiation above 30 MeV.The established ICP-MS internal standard method enables accurate quantitative detection of germanium and impurity elements.The electrochemical method allows for simple and rapid dissolution of the gallium-nickel alloy layer without heating.The combined use of chelating resin and gel resin for separation and purification yields germanium-containing sample solutions with high recovery rates and purity.Through the aforementioned process simulation studies,a simulated process flow for target preparation,target dissolution,analytical detection,and separation-purification has been established,providing technical support for the production of ^(68)Ge using medium-high energy cyclotrons.

关 键 词：^(68)Ge 镓镍合金 电化学 分离纯化 

分 类 号：TL921.1[核科学技术—核燃料循环与材料]