基于中高能回旋加速器生产^(68)Ge核素的产额及产物模拟研究  

Simulation Study on the Yield and Reaction Products of ^(68)Ge Nuclide Produced by Medium High Energy Cyclotron

作　　者：赵云龙 安世忠[1] 官国英 王哲 王飞[1] 李勇 魏素敏[1] 周佳 王宇 赵鹏飞 ZHAO Yunlong;AN Shizhong;GUAN Guoying;WANG Zhe;WANG Fei;LI Yong;WEI Sumin;ZHOU Jia;WANG Yu;ZHAO Pengfei(China Institute of Atomic Energy,Beijing 102413,China)

机构地区：[1]中国原子能科学研究院,北京102413

出　　处：《同位素》2024年第6期555-561,共7页Journal of Isotopes

基　　金：国防科工局“核能开发”科研项目(HNKF202221(36))。

摘　　要：^(68)Ge是正电子扫描(PET)诊断显像用放射性核素^(68)Ga的母体核素,^(68)Ge通过^(68)Ge/^(68)Ga发生器转化为^(68)Ga已在临床诊断显像中获得应用。国内目前有13种^(68)Ga标记的放射性药物已进入临床,在神经内分泌肿瘤、前列腺癌等肿瘤显像方面具有较好的应用前景。随着^(68)Ga放射性药物的获批和大量使用,^(68)Ge在国内外市场的应用前景广阔。此外,^(68)Ge也可以作为PET扫描仪的校准源而获得广泛使用。中国原子能科学研究院目前计划建造一台专用于放射性医用同位素生产、能量为75 MeV、最高束流流强800μA的强流质子回旋加速器,将重点开展^(68)Ge的生产。本研究利用蒙特卡罗程序FLUKA对中高能质子回旋加速器辐照镓镍合金靶和铌镓胶囊靶等方式生产^(68)Ge核素的产额、反应产物、杂质核素产额随冷却时间的变化、影响分离工艺的长寿命核素情况等进行详细模拟,本结果可为中高能质子回旋加速器生产^(68)Ge的生产和分离纯化提供参考。^(68)Ge is the parent nuclide of radioactive nuclide ^(68)Ga used in positron emission tomography(PET)diagnostic imaging,which is converted into ^(68)Ga by a ^(68)Ge/^(68)Ga generator for clinical diagnostic imaging applications.Currently,there are 13 kinds of ^(68)Ga labeled radiopharmaceuticals in China that have entered clinical practice and have good application prospects in tumor imaging such as high-grade endocrine tumors and prostate cancer.Therefore,with the approval and widespread use of ^(68)Ga radiopharmaceuticals,^(68)Ge has broad application prospects in both domestic and international markets.In addition,^(68)Ge can also be widely used as a calibration source for PET scanners.China Institute of Atomic Energy(CIAE)plans to build a 75 MeV cyclotron with the maximum beam current of 800μA and the proton energy range of 75 MeV.It will be used to focus on the production of ^(68)Ge nuclide.This article used the Monte Carlo program FLUKA to simulate in detail the production of ^(68)Ge nuclides yield,reaction products,the variation of impurity nuclide production with cooling time,and long-life nuclides affecting separation processes by irradiating gallium nickel alloy targets and niobium gallium capsule targets in medium to high energy proton cyclotron.The simulation results can provide the useful reference for the production,separation,and purification of ^(68)Ge in medium to high energy cyclotron.

关 键 词：75 MeV回旋加速器 ^(68)Ge 蒙特卡罗模拟 同位素生产 

分 类 号：TL921.1[核科学技术—核燃料循环与材料]