十味龙胆花颗粒联合特布他林治疗儿童急性支气管炎的临床研究  

Clinical study of Shiwei Longdanhua Granules combined with terbutaline in treatment of acute bronchitis in children

作　　者：王军[1] 刘爱红[1] 崔捷[1] WANG Jun;LIU Aihong;CUI Jie(Department of Respiration,Shanxi Children's Hospital,Taiyuan 030013,China)

机构地区：[1]山西省儿童医院呼吸科,山西太原030013

出　　处：《现代药物与临床》2024年第11期2853-2857,共5页Drugs & Clinic

摘　　要：目的探讨十味龙胆花颗粒联合硫酸特布他林雾化液治疗儿童急性支气管炎的临床疗效。方法将2021年7月—2024年5月在山西省儿童医院就诊的88例急性支气管炎患儿作为研究对象,按随机数字表法将所有患儿分为对照组和治疗组,各44例。对照组通过雾化器吸入硫酸特布他林雾化液,3次/d,20 kg以下儿童每次吸入半瓶,20 kg及以上儿童每次吸入1瓶。治疗组在对照组基础上开水冲服十味龙胆花颗粒,1袋/次,3次/d。两组在治疗7 d后分析治疗效果。比较两组患儿的主症状消失时间、咳嗽病情、肺通气功能指标、血清炎症指标。结果治疗组的总有效率明显高于对照组(95.45%vs81.82%,P<0.05)。治疗组发热、肺啰音、咳嗽、咯痰消失时间均短于对照组(P<0.05)。治疗后,两组的咳嗽程度评分表(CET)评分均显著减小(P<0.05),且治疗组CET评分明显小于对照组(P<0.05)。治疗后,两组的第1秒用力呼气容积(FEV_(1))、最大呼气流量(PEF)均比治疗前高(P<0.05),且治疗组FEV_(1)、PEF较对照组更高(P<0.05)。治疗后,两组血清白细胞介素-2(IL-2)水平高于治疗前,血清白细胞介素-8(IL-8)、鳞状细胞癌相关抗原(SCCA)水平低于治疗前(P<0.05);治疗组血清IL-2水平高于对照组,血清IL-8、SCCA水平低于对照组(P<0.05)。结论十味龙胆花颗粒联合硫酸特布他林雾化液可提高儿童急性支气管炎的疗效,促进患儿症状改善,减轻咳嗽程度,改善肺通气功能,降低炎症反应。Objective To explore the clinical efficacy of Shiwei Longdanhua Granules combined with Terbutaline Sulphate Solution for nebulization in treatment of acute bronchitis in children.Methods 88 Children with acute bronchitis in Shanxi Children's Hospital from July 2021 to May 2024 were divided into control group and treatment group by random number table method,with 44 cases in each group.Children in the control group inhaled Terbutaline Sulphate Solution for nebulization with a nebulizer,3 times daily.Children under 20 kg inhaled half a bottle each time,and children over 20 kg inhaled one bottle each time.On the basis of the control group,children in the treatment group were po administered with Shiwei Longdanhua Granules in boiling water,1 bag/time,3 times daily.The treatment effect of two groups of children were analyze after 7 d of treatment.The disappearance times of main symptoms,cough condition,pulmonary ventilation function indicators,and serum inflammation indicators between two groups of children were compared.Results The total effective rate of the treatment group was significantly higher than that of the control group(95.45%vs 81.82%,P<0.05).The disappearance times of fever,pulmonary rales,cough,and sputum in the treatment group was lower than those in the control group(P<0.05).After treatment,the CET scores of both groups were significantly decreased(P<0.05),and the CET scores in the treatment group were lower than those in the control group(P<0.05).After treatment,FEV_(1) and PEF of both groups were higher than those before treatment(P<0.05),and FEV_(1) and PEF in the treatment group was higher than those in the control group(P<0.05).After treatment,the serum levels of IL-2 in both groups were higher than those before treatment,while serum levels of IL-8 and SCCA levels were lower than those before treatment(P<0.05).The serum levels of IL-2 levels in the treatment group were higher than those in the control group after treatment,while serum levels of IL-8 and SCCA levels were lower than those in the con

关 键 词：十味龙胆花颗粒 硫酸特布他林雾化液 儿童急性支气管炎 咯痰消失时间 咳嗽程度评分表评分 第1秒用力呼气容积 最大呼气流量 白细胞介素-2 白细胞介素-8 鳞状细胞癌相关抗原 

分 类 号：R974[医药卫生—药品] R985[医药卫生—药学]