蒲地蓝消炎口服液联合曲安奈德治疗口腔扁平苔藓的临床研究  

Clinical study of Pudilan Xiaoyan Oral Liquid combined with triamcinolone acetonide in treatment of oral lichen planus

作　　者：张宗敏[1,2,3] 那思家 郭治辰 ZHANG Zongmin;NA Sijia;GUO Zhichen(Shaanxi Province Key Laboratory of Craniofacial Precision Medicine,Hospital of Stomatology Xi'an Jiaotong University,Xi'an 710004,China;Shaanxi Clinical Research Center for Dental and Maxillofacial Diseases,Hospital of Stomatology Xi'an Jiaotong University,Xi'an 710004,China;Outpatient Department of Maxillofacial Surgery,Hospital of Stomatology Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学口腔医院陕西省颅颌面精准医学研究重点实验室,陕西西安710004 [2]西安交通大学口腔医院陕西省牙颌疾病临床研究中心,陕西西安710004 [3]西安交通大学口腔医院颌面外科门诊,陕西西安710004

出　　处：《现代药物与临床》2024年第11期2928-2931,共4页Drugs & Clinic

基　　金：陕西省自然科学基础研究计划项目(2024JC-YBQN-0769)。

摘　　要：目的探讨蒲地蓝消炎口服液联合曲安奈德口腔软膏治疗口腔扁平苔藓的效果。方法选取2023年7月—2024年6月西安交通大学口腔医院收治的96例口腔扁平苔藓患者,按随机数字表法将患者分为对照组和治疗组,每组各48例。对照组给予曲安奈德口腔软膏,每次挤出1 cm药膏,均匀轻涂于口腔病损表面,3次/d。治疗组在对照组基础上口服蒲地蓝消炎口服液,10 mL/次,3次/d。两组患者持续治疗28 d。比较两组患者的临床疗效、疼痛程度、病损面积和血清炎症指标。结果治疗组患者的总有效率为95.83%,对照组患者的总有效率为82.61%,组间比较差异显著(P<0.05)。治疗后,两组的疼痛程度、病损面积均比治疗前小(P<0.05);治疗组的疼痛程度、病损面积比对照组小(P<0.05)。治疗后,两组患者的血清白细胞介素(IL)-12、T-细胞表达分泌因子(RANTES)、IL-17水平显著减小(P<0.05);治疗组患者的血清IL-12、RANTES、IL-17水平小于对照组(P<0.05)。结论蒲地蓝消炎口服液联合曲安奈德口腔软膏可提高口腔扁平苔藓的疗效,降低病损面积和疼痛程度,减轻炎症程度。Objective To investigate the effect of Pudilan Xiaoyan Oral Liquid combined with Triamcinolone Acetonide Dental Paste in treatment of oral lichen planus.Methods 96 Patients with oral lichen planus from Hospital of Stomatology Xi'an Jiaotong University were divided into control group and treatment group using a random number table method,with 48 patients in each group.Patients in the control group received Triamcinolone Acetonide Dental Paste,squeezing out 1 cm of ointment each time and applying it evenly and lightly on the surface of the oral lesion,3 times daily.Based on the control group,patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid,10 mL per time,3 times daily.Patients in two groups were treated for 28 d.The clinical efficacy,pain degree,lesion area,and serum inflammatory indicators between two groups of patients were compared.Results The total effective rate in the treatment group was 95.83%,and that in the control group was 82.61%,with significant difference between groups(P<0.05).The pain degree and lesion area of both groups after treatment were smaller than those before treatment(P<0.05),and the pain degree and lesion area in the treatment group were smaller than those in the control group(P<0.05).After treatment,serum levels of IL-12,RANTES,and IL-17 in both groups were significantly decreased(P<0.05),and these indexes in the treatment group were lower than those in the control group(P<0.05).Conclusion Pudilan Xiaoyan Oral Liquid combined with Triamcinolone Acetonide Dental Paste can improve the efficacy of oral lichen planus,significantly reduce the lesion area and pain degree,and reduce the degree of inflammation.

关 键 词：蒲地蓝消炎口服液 曲安奈德口腔软膏 口腔扁平苔藓 疼痛程度 病损面积 白细胞介素-12 T-细胞表达分泌因子 白细胞介素-17 

分 类 号：R988.2[医药卫生—药品]