中药活性成分治疗功能性便秘的药理作用研究进展  

Pharmacological research progress on active ingredients in traditional Chinese medicine in treating functional constipation

作　　者：洪关婷 杨勇军 HONG Guanting;YANG Yongjun(Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院,四川南充637000

出　　处：《现代药物与临床》2024年第11期2970-2976,共7页Drugs & Clinic

基　　金：四川省中医药管理局科学技术研究专项项目(2018LC020)。

摘　　要：功能性便秘为临床常见病、多发病,当前治疗功能性便秘的药物主要包括渗透性泻药和促进胃肠道动力药,但这些药物的长期使用或使用不当可能引起不良反应。中药活性成分可通过调节肠道菌群结构、调节胃肠激素水平、促进Cajal间质细胞增殖、调控肠神经系统和肠道微环境、调控水通道蛋白表达治疗功能性便秘。总结了中药活性成分治疗功能性便秘的药理作用研究进展,以期为功能性便秘用药提供参考。Functional constipation is a common and frequently occurring clinical disease.The current drugs used to treat functional constipation mainly include osmotic laxatives and gastrointestinal motility promoting drugs.However,long-term or improper use of these drugs may cause adverse reactions.The active ingredients in traditional Chinese medicine can treat functional constipation by regulating intestinal flora structure,adjusting gastrointestinal hormone levels,promoting Cajal interstitial cell proliferation,regulating the intestinal nervous system and intestinal microenvironment,and regulating aquaporin expression.This article summarizes the pharmacological research progress of active ingredients in traditional Chinese medicine for the treatment of functional constipation,in order to provide reference for the medication of functional constipation.

关 键 词：中药活性成分 功能性便秘 肠道菌群 胃肠激素 CAJAL间质细胞 肠神经系统 肠道微环境 水通道蛋白 

分 类 号：R285[医药卫生—中药学] R286.5[医药卫生—中医学]