黄芩苷抗流感病毒的作用机制研究进展  

Research progress on mechanism of baicalin against influenza virus

作　　者：王志国 钟宪澎 许传杰[2] WANG Zhiguo;ZHONG Xianpeng;XU Chuanjie(Department of Pharmacy,Jilin University Hospital,Changchun 130012,China;Department of Pathology,Jilin University Second Hospital,Changchun 130041,China)

机构地区：[1]吉林大学校医院药剂科,吉林长春130012 [2]吉林大学第二医院病理科,吉林长春130041

出　　处：《现代药物与临床》2024年第11期2983-2987,共5页Drugs & Clinic

基　　金：吉林省科技发展计划项目(YDZJ202301ZYTS057)。

摘　　要：流感是人类最常见的呼吸道疾病之一,流感病毒基因突变率高、病毒传播效率高、耐药性迅速出现,造成临床抗病毒治疗的疗效有限。黄芩苷是黄芩中黄酮类化合物,具有多种活性。黄芩苷可通过抑制病毒生长,限制病毒侵入宿主细胞,降低病毒引起的炎症反应,降低病毒引起的肺组织细胞凋亡,纠正病毒引起的肺组织高凝状态发挥抗流感病毒作用。总结了黄芩苷抗流感病毒的药理作用及其作用机制研究进展,为流感的药物治疗提供思路。Influenza is one of the most common respiratory diseases in humans,and influenza virus has a high mutation rate of influenza virus genes,high virus transmission efficiency,and rapid emergence of drug resistance,resulting in limited efficacy of clinical antiviral treatment.Baicalin is a flavonoid compound in Scutellariae Radix,which has various activities.Baicalin can exert anti-influenza virus effects by inhibiting virus growth,limiting virus invasion into host cells,reducing virus-induced inflammatory responses,lowering virus-induced lung tissue cell apoptosis,and correcting virus-induced hypercoagulable state of lung tissue.This article summarizes the pharmacological effects and mechanisms of baicalin against influenza virus,providing ideas for the drug treatment of influenza.

关 键 词：黄芩苷 流感病毒 病毒生长 宿主细胞 炎症反应 细胞凋亡 高凝状态 

分 类 号：R285[医药卫生—中药学] R286.4[医药卫生—中医学]