基于MRI的失眠障碍患者大脑皮层厚度研究  

A cortical thickness study of insomnia disorder patients based on MRI

作　　者：陈巍[1,2] 王慧 刘子怡[1] 尚宇 李海宁 韩文轩 朱芊各 张明 CHEN Wei;WANG Hui;LIU Ziyi;SHANG Yu;LI Haining;HAN Wenxuan;ZHU Qiange;ZHANG Ming(Xi’an Jiaotong University,Xi’an 710049,China;Department of Radiology,Ankang Hospital of Traditional Chinese Medicine,Ankang,Shaanxi Province 725000,China;School of Future Technology,Xi’an Jiaotong University,Xi’an 710049,China;Department of Medical Imaging,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学,陕西西安710049 [2]安康市中医医院影像科,陕西安康725000 [3]西安交通大学未来技术学院,陕西西安710049 [4]西安交通大学第一附属医院医学影像科,陕西西安710061

出　　处：《实用放射学杂志》2024年第11期1766-1769,共4页Journal of Practical Radiology

摘　　要：目的探讨失眠障碍(ID)患者大脑皮层厚度的变化。方法收集32例ID患者(ID组)和30例健康对照(HC)(HC组)的高分辨率MRI数据。采用统计参数映射12(SPM12)软件,以年龄、性别、受教育程度为协变量,对2组大脑皮层厚度进行双样本t检验分析。提取有统计学差异脑区的皮层厚度与睡眠、情绪相关量表进行Pearson相关分析。结果与HC组相比,ID组出现多个脑区皮层厚度显著降低,具体包括左侧脑岛、梭状回、眶额叶、颞上回、颞中回、枕外叶和右侧尾状前扣带回[P<0.05,家族误差(FWE)校正],且扣带回皮层厚度的减少与匹兹堡睡眠质量指数(PSQI)得分呈负相关(r=-0.437,P=0.012)。结论ID患者中与睡眠和情绪相关的多个脑区的皮层厚度显著降低,这为理解ID的病理生理机制提供了潜在的神经影像学证据。Objective To investigate the changes of cortical thickness in patients with insomnia disorder(ID).Methods Highresolution MRI data were collected from 32 ID patients(ID group)and 30 healthy controls(HC)(HC group).The cortical thickness of both groups were analyzed using statistical parametric mapping 12(SPM12)software,while considering age,gender,and educational level as covariates.The cortical thickness in brain regions showed statistically significant differences was extracted for Pearson’s correlation analyses with sleep and mood-related scales.Results Compared with the HC group,the ID group exhibited significantly decreased cortical thickness in brain regions such as the left insula,fusiform gyrus,orbitofrontal lobe,superior temporal gyrus,middle temporal gyrus,lateral occipital lobe and right caudal anterior cingulate gyrus[P<0.05,family-wise error(FWE)correction].Furthermore,reduced cortical thickness of the cingulate gyrus was negatively correlated with the Pittsburgh sleep quality index(PSQI)score(r=-0.437,P=0.012).Conclusion The cortical thickness of several brain regions associated with sleep and mood are significantly reduced in patients with ID,providing potential neuroimaging evidence for understanding the pathophysiological mechanism of ID.

关 键 词：失眠障碍 皮层厚度 磁共振成像 

分 类 号：R256.23[医药卫生—中医内科学] R338.25[医药卫生—中医学] R445.2