瘤周结节CT定量特征预测胸腺上皮肿瘤危险度  

Quantitative CT features of peritumoral nodules for predicting the risk of thymic epithelial tumors

作　　者：郭炜 和清源[1] 王晓华[1] 袁慧书[1] GUO Wei;HE Qingyuan;WANG Xiaohua;YUAN Huishu(Department of Radiology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院放射科,北京100191

出　　处：《实用放射学杂志》2024年第11期1784-1787,共4页Journal of Practical Radiology

基　　金：国家自然基金面上项目(12271056);北京大学第三医院创新转化基金科创研发项目(Y75508-03)。

摘　　要：目的探讨瘤周结节CT定量特征对预测胸腺上皮肿瘤(TETs)危险度的价值。方法回顾性分析108例经病理诊断为TETs的患者。根据WHO胸腺肿瘤分类,将患者分为高危组和低危组。CT定量特征包括瘤周结节的长径、体积、质量、瘤周结节与主瘤灶距离。使用Mann-Whitney U检验评估这些特征的价值,并使用受试者工作特征(ROC)曲线确定阈值。结果108例TETs患者中45例CT可见瘤周结节,高危组30例和低危组15例。不同观察者间一致性较好,组内相关系数(ICC)0.886~0.907。高危组瘤周结节的长径、体积和质量均大于低危组(P<0.05),与主瘤灶距离组间差异无统计学意义(P>0.05)。CT定量特征中,瘤周结节的质量在预测TETs危险度方面具有最佳的诊断效能,对应的阈值为27.84 mg,曲线下面积(AUC)0.889,敏感度83.3%,特异度87.5%,准确性85.3%。结论瘤周结节的CT定量特征对预测TETs的危险度有一定价值,尤以质量最佳。Objective To explore the predicting value of quantitative CT features of peritumoral nodules for the risk of thymic epithelial tumors(TETs).Methods A total of 108 patients with TETs confirmed by pathology were analyzed retrospectively.According to the WHO classification of thymic tumors,the patients were divided into high-risk group and low-risk group.The quantitative CT features included the long diameter,volume,mass,and distance between peritumoral nodules and main tumor.The values of these features were assessed using the Mann-Whitney U test,and the thresholds were determined using the receiver operating characteristic(ROC)curve.Results Among 108 TETs patients,there were 45 patients with peritumoral nodules on chest CT,including 30 high-risk group and 15 low-risk group,respectively.Interobserver consistencies were well with intraclass correlation coefficient(ICC)between 0.886 and 0.907.The long diameter,volume,and mass of peritumoral nodules were greater in the high-risk group than in the lowrisk group(P<0.05),and there was no significant difference in the distance to the main tumor(P>0.05).The mass of peritumoral nodules had the best diagnostic performance in predicting TETs risk,and the thresholds was 27.84 mg with the area under the curve(AUC)of 0.889,sensitivity of 83.3%,specificity of 87.5%,and accuracy of 85.3%,respectively.Conclusion The quantitative CT features of peritumoral nodules especially mass can be useful in predicting the risk of TETs.

关 键 词：计算机体层成像 胸腺上皮肿瘤 瘤周结节 

分 类 号：R814.42[医药卫生—影像医学与核医学] R736.3[医药卫生—放射医学]