T1_(ρ)、T2 mapping定量评估长期久坐对腰椎间盘退行性变的影响  

Quantitative assessment of the impact of prolonged sitting on lumbar intervertebral disc degeneration using T1_(ρ)and T2 mapping

作　　者：曾琪 宋玲玲 梁晨 聂莉莎 何伟欣 张紫微 眭贺 ZENG Qi;SONG Lingling;LIANG Chen;NIE Lisha;HE Weixin;ZHANG Ziwei;SUI He(Department of Radiology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;GE Healthcare,MR Research China,Beijing 100076,China)

机构地区：[1]贵州医科大学附属医院放射科,贵州贵阳550004 [2]GE医疗中国磁共振科研部,北京100076

出　　处：《实用放射学杂志》2024年第11期1857-1861,共5页Journal of Practical Radiology

摘　　要：目的应用MRI T1_(ρ)、T2 mapping探讨久坐对腰椎间盘退变的影响。方法对年龄相匹配的25例出租车司机(久坐组)和24例非长期久坐人群(对照组)进行常规腰椎MRI、T1_(ρ)及T2 mapping检查。对不同Pfirrmann分级的椎间盘前纤维环(AAF)、髓核(NP)、后纤维环(PAF)的T1_(ρ)值、T2值差异进行方差分析、Spearman相关检验及绘制受试者工作特征(ROC)曲线,2组间比较采用独立样本t检验。结果2组所有PfirrmannⅠ~Ⅱ级NP及PfirrmannⅡ~Ⅳ级AAF、NP、PAF的T1_(ρ)值和T2值均有统计学差异(P<0.05)。T1_(ρ)值和T2值与Pfirrmann等级均呈负相关。Pfirrmann各级NP的T1_(ρ)值曲线下面积(AUC)分别为0.928、0.987、0.968,NP的T_(2)值AUC分别为0.777、0.966、0.975。久坐组L4/L5 NP及L5/S1的AAF、NP、PAF的T1_(ρ)值及T_(2)值均低于对照组(P<0.05)。结论T1_(ρ)检测腰椎间盘退变的能力优于T2 mapping。久坐更易引起L4/L5、L5/S1椎间盘退变。Objective To explore the impact of prolonged sitting on lumbar disc degeneration using MRI T1_(ρ)and T2 mapping.Methods A total of 25 taxi drivers(prolonged sitting group)and 24 age-matched non-prolonged sitting volunteers(control group)underwent routine lumbar MRI,T1_(ρ),and T2 mapping.The differences of T1_(ρ)and T2 values for different Pfirrmann grades of anterior annulus fibrosus(AAF),nucleus pulposus(NP),and posterior annulus fibrosus(PAF)were analyzed using Variance analysis,Spearman correlation test,and receiver operating characteristic(ROC)curve was drawn,with independent t-tests was used for between-group comparisons.Results Statistically significant differences were observed in T1_(ρ)and T_(2)values for all PfirrmannⅠ-Ⅱgrades NP and PfirrmannⅡ-Ⅳgrades AAF,NP,and PAF in both groups(P<0.05).Both T1_(ρ)and T2 values were negatively correlated with Pfirrmann grades.The area under the curve(AUC)of T1_(ρ)values for NP at each Pfirrmann grade were 0.928,0.987,and 0.968,respectively,while the AUC of T2 values for NP were 0.777,0.966,and 0.975,respectively.The T1_(ρ)and T_(2)values of L4/L5 NP and L5/S1 AAF,NP,and PAF were lower in the prolonged sitting group compared to the control group(P<0.05).Conclusion T1_(ρ)is superior to T2 mapping in detecting lumbar disc degeneration.Prolonged sitting is more likely to cause degeneration of L4/L5 and L5/S1 intervertebral discs.

关 键 词：磁共振成像 T1_(ρ) T2 mapping 腰椎间盘退行性变 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681.5[医药卫生—诊断学]