吲哚布芬用于老年冠心病患者PCI后治疗的有效性及安全性  

Efficacy and safety of indobufen in the treatment of elderly patients with coronary heart disease after PCI

作　　者：陆翊超 顾剑 陶金松[1] 李健[1] 李伟章[1] LU Yichao;GU Jian;TAO Jinsong;LI Jian;LI Weizhang(Department of Cardiology,Jiangyin People's Hospital,Jiangyin 214400,CHINA)

机构地区：[1]江苏江阴市人民医院心内科,江苏214400

出　　处：《江苏医药》2024年第11期1094-1098,共5页Jiangsu Medical Journal

基　　金：江阴市卫生健康委员会青年科研项目(Q202205)。

摘　　要：目的 探讨吲哚布芬用于老年冠心病患者经皮冠状动脉介入(PCI)后治疗的有效性及安全性。方法 接受PCI治疗的115例老年冠心病患者,随机分为两组。在氯吡格雷治疗的基础上,阿司匹林组(59例)加用阿司匹林肠溶片,吲哚布芬组(56例)加用吲哚布芬片。比较两组基本临床资料和PCI相关资料。随访6个月,比较两组服药期间不良反应和不良心脑血管事件(MACCE)以及严重出血事件的发生风险。结果 两组患者基本资料相仿(P>0.05)。服药期间,吲哚布芬组不良反应总发生率低于阿司匹林组(10.7%vs.25.4%)(P<0.05)。随访6个月,吲哚布芬组终点事件、MACCE、严重出血事件发生风险均低于阿司匹林组,但差异无统计学意义(P>0.05)。结论 与应用阿司匹林相比,老年冠心病患者PCI治疗后应用吲哚布芬同样有效,不增加出血的发生风险,并且服药期间不良反应减少。Objective To explore the efficacy and safety of indobufen in the treatment of elderly patients with coronary heart disease(CHD)after percutaneous coronary artery intervention(PCI).Methods A total of 115 elderly patients with CHD underwent PCI were randomly divided into two groups.On the basis of oral clopidogrel,group A(59 cases)received aspirin enteric-coated tablets and group B(56 cases)received indobufen tablets treatment.The basic clinical and PCI data were compared between the two groups.The patients were followed-up for 6 months.The incidences of adverse responses and the risk of major unconscious-vascular events(MACCE)and severe bleeding events were observed and compared between the two groups.Results sThere were no significant differences in the basic data between the two groups(P>0.05).The total incidence of adverse reactions during medication in group B was lower than that in group A(10.7%vs.25.4%)(P<0.05).During 6 months of follow-up,the risk of end point event,MACCE and severe bleeding in group B were slightly lower than those in group A(P>0.05).Conclusion Compared with aspirin,indobufen was equally effective in elderly CHD patients after PCI,with reducing adverse reactions during medication but not increasing the risk of bleeding.

关 键 词：吲哚布芬 阿司匹林 冠心病 老年 

分 类 号：R541[医药卫生—心血管疾病]