加味升降散治疗小儿疱疹性咽峡炎心脾积热证40例临床观察  

Clinical observation on modified Shengjiang San(升降散)in the treatment of 40 cases of pediatric herpangina with excess heat in the heart and spleen pattern

作　　者：秦福海 白冬梅 于峰伟 QIN Fuhai;BAI Dongmei;YU Fengwei(Department of Pediatrics,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian,Henan,463000,China)

机构地区：[1]驻马店市中医院儿科,河南驻马店463000

出　　处：《中医儿科杂志》2024年第6期42-46,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题(2023ZY2189)。

摘　　要：目的观察加味升降散治疗小儿疱疹性咽峡炎心脾积热证的临床疗效。方法选取2022年12月至2023年5月驻马店市中医院儿科收治的疱疹性咽峡炎心脾积热证患儿80例,采用随机数字表法分为治疗组和对照组,各40例。对照组予利巴韦林喷雾治疗,治疗组予加味升降散治疗,2组均5 d为1个疗程,1个疗程后统计临床疗效,比较治疗前后中医证候积分、血清炎症因子水平变化以及安全性。结果治疗组总有效率为97.50%(39/40),显著高于对照组的85.00%(34/40),2组比较,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组中医证候积分较治疗前均降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前,2组血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述指标水平较治疗前均降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。2组治疗期间,生命体征(体温、血压、呼吸、静息心率)、血常规、尿常规、心电图及肝肾功能检查,均未发生不良事件及药物不良反应。结论加味升降散治疗小儿疱疹性咽峡炎心脾积热证临床疗效满意,可显著降低患儿中医证候积分,抑制机体炎症反应,安全性较高,值得临床推广应用。Objective To observe the clinical efficacy of modified Shengjiang San(升降散)in the treatment of pediatric herpangina with excess heat in the heart and spleen pattern.Methods A total of 80 pediatric patients with herpangina of excess heat in the heart and spleen pattern admitted to the Pediatric Department of Zhumadian Traditional Chinese Medicine Hospital from December 2022 to May 2023 were selected and randomly divided into a treatment group and a control group using a random number table,with 40 patients in each group.The control group was treated with ribavirin spray,while the treatment group was treated with modified Shengjiang San.Both groups were treated for 5 days as one course of treatment.After one consecutive course of treatment,the clinical efficacy was evaluated,and comparisons were made in terms of changes in traditional Chinese medicine(TCM)syndrome scores,serum inflammatory factor levels,and safety before and after treatment.Results The total effective rate in the treatment group was 97.50%(39/40),significantly higher than the 85.00%(34/40)in the control group.The difference between the two groups was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in TCM syndrome scores between the two groups(P>0.05),indicating comparability.After treatment,the TCM syndrome scores of both groups decreased compared with those before treatment,with statistically significant differences compared with the pre-treatment scores within the same group(P<0.05).The decrease was more significant in the treatment group(P<0.05).Before treatment,there were no statistically significant differences in serum levels of hs-CRP,IL-6 and TNF-αbetween the two groups(P>0.05),indicating comparability.After treatment,the levels of these indicators decreased in both groups compared with those before treatment,with statistically significant differences compared with the pre-treatment levels within the same group(P<0.05).The decrease was more significant in the treatment group(P<0.05)

关 键 词：疱疹性咽峡炎 小儿 心脾积热证 加味升降散 临床观察 

分 类 号：R256.1[医药卫生—中医内科学]