Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of periimplant lesion  

作　　者：Yiru Xia Zhaowenbin Zhang Kecong Zhou Zhikai Lin Rong Shu Yuze Xu Zhen Zeng Jiang Chang Yufeng Xie 

机构地区：[1]Department of Periodontology,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai,China [3]Joint Centre of Translational Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China [4]Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China [5]State Key Laboratory of High-Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China [6]Key Laboratory of Rehabilitation Medicine in Sichuan Province,West China Hospital,Sichuan University,Chengdu,China [7]Department of Periodontology,Shanghai Stomatological Hospital&School of Stomatology,Fudan University,Shanghai,China [8]Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Fudan University,Shanghai,China

出　　处：《Regenerative Biomaterials》2024年第5期90-105,共16页再生生物材料（英文版）

基　　金：supported by National Natural Science Foundation of China(81991500,81991503);Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital,Shanghai JiaoTong University School of Medicine(JYJC201904);Science and Technology Commission of Shanghai Municipality(18ZR1422400);Innovative Research Team of High-level Local Universities in Shanghai(SSMU-ZDCX20180900);Open Project of the Key Laboratory of Rehabilitation Medicine in Sichuan Province of China(KFYXSZDSYS-01);the Natural Science Foundation of Sichuan Province of China(2022NSFSC1469).

摘　　要：Peri-implant lesion is a grave condition afflicting numerous individuals with dental implants.It results from persistent periodontal bacteria accumulation causing inflammation around the implant site,which can primarily lead to implant loosening and ultimately the implant loss.Early-stage peri-implant lesions exhibit symptoms akin to gum disease,including swelling,redness and bleeding of the gums surrounding the implant.These signs indicate infection and inflammation of the peri-implant tissues,which may result in bone loss and implant failure.To address this problem,a thermionic strategy was applied by designing a cuprorivaite–hardystonite bioceramic/alginate composite hydrogel with photothermal and Cu/Zn/Si multiple ions releasing property.This innovative approach creates a thermionic effect by the release of bioactive ions(Cu^(2+)and Zn^(2+)and SiO_(3)^(2−))from the composite hydrogel and the mild heat environment though the photothermal effect of the composite hydrogel induced by near-infrared light irradiation.The most distinctive advantage of this thermionic effect is to substantially eliminate periodontal pathogenic bacteria and inhibit inflammation,while simultaneously enhance peri-implant osseointegration.This unique attribute renders the use of this composite hydrogel highly effective in significantly improving the survival rate of implants after intervention in peri-implant lesions,which is a clinical challenge in periodontics.This study reveals application potential of a new biomaterial-based approach for peri-implant lesion,as it not only eliminates the infection and inflammation,but also enhances the osteointegration of the dental implant,which provides theoretical insights and practical guidance to prevent and manage early-stage peri-implant lesion using bioactive functional materials.

关 键 词：BIOCERAMICS composite hydrogel thermionic effect peri-implant lesion 

分 类 号：R318[医药卫生—生物医学工程]