NMP22/Cr值在基层医疗单位膀胱癌诊断中的临床应用价值  

The Clinical Application Value of Urinary NMP22/Cr Ratio in Clinical Diagnosis and Treatment of Bladder Cancer in Primary Medical Units

作　　者：王海龙 师宏斌[3] WANG Hailong;SHI Hongbin(First Clinical Medical College of Ningxia Medical University,Yinchuan 750004,China;The Wuzhong People's Hospital Affiliated to Ningxia Medical University,Wuzhong 751100,China;General Hospital of Ningxia Medical University,First Clinical Medical College of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学第一临床医学院,银川750004 [2]宁夏医科大学附属吴忠市人民医院,吴忠751100 [3]宁夏医科大学总医院,宁夏医科大学第一临床医学院,银川750004

出　　处：《宁夏医科大学学报》2024年第11期1141-1145,共5页Journal of Ningxia Medical University

基　　金：宁夏医科大学校级课题(XM2019181)。

摘　　要：目的分析尿核基质蛋白22(NMP22)/肌酐(Cr)比值在膀胱癌诊断中的临床应用价值。方法选取膀胱癌组(非肌层浸润性膀胱癌221例、肌层浸润性膀胱癌44例)、结石组(泌尿系统结石90例)和对照组(体检健康志愿者50例),检测各组患者尿NMP22及Cr的含量,采用ROC曲线分析其对膀胱癌诊断的作用。结果膀胱癌组尿液中NMP22/Cr值高于结石组和对照组(P均<0.001)。肌层浸润性膀胱癌NMP22/Cr值较非肌层浸润性膀胱癌显著升高,同时病理高级别肿瘤较低级别肿瘤NMP22/Cr值也升高(P均<0.001)。NMP22/Cr诊断膀胱癌的AUC值为0.808(95%CI:0.767~0.849)。当取NMP22/Cr值为19.55 ng·mg^(-1)的临界值时,敏感性为64.2%,特异性为93.6%。结论尿NMP22/Cr检测能够提高对膀胱癌的诊断效率,可以作为基层单位临床诊断膀胱癌的重要辅助检查。Objective To analyze the clinical value of urinary nuclear matrix protein 22(NMP22)/creatinine(Cr)ratio in the diagnosis of bladder cancer.Methods The study cohort comprised three groups:the bladder cancer group,which included 221 ases of non-muscle-invasive bladder cancer and 44 cases of muscle-invasive bladder cancer;the stone group,consisting of 90 cases of urinary system stones;and a control group of 50 healthy volunteers who underwent physical examinations.Urinary levels of NMP22 and creatinine(Cr)were measured across all groups.Receiver operating characteristic(ROC)curves were employed to evaluate the diagnostic efficacy of these biomarkers in bladder cancer detection.Results The ratio of NMP22/Cr in urine of patients with bladder cancer was significantly higher than that of patients with non cancerous diseases(P<0.001)and healthy controls(P<0.001).The level of NMP22/Cr is significantly correlated with pathological T staging(P<0.001)and grading(P<0.001).The AUC of bladder cancer diagnosed by NMP22/Cr was 0.808(95%CI:0.767-0.849).When the cut-off value of NMP22/Cr is 19.55 ng·mg^(-1),the sensitivity is 64.2%and the specificity is 93.6%.Conclusion Urine NMP22/Cr detection can improve the diagnostic efficiency of bladder cancer,and can be an important auxiliary examination for clinical diagnosis of bladder cancer in grass-roots units.

关 键 词：膀胱癌 尿核基质蛋白 诊断 预后 

分 类 号：R446.1[医药卫生—诊断学]