基于网络药理学探讨杏仁-黄芩治疗新型冠状病毒肺炎机制  

Based on network pharmacology to explore mechanism of Armeniacae Semen Amarum-Scutellariae Radix on treatment of corona virus disease 2019

作　　者：王劲松[1] 游晓旭 陈迪 解博文 贺森 WANG Jingsong;YOU Xiaoxu;CHEN Di;XIE Bowen;HE Sen(Beijing University of Traditional Chinese Medicine Affiliated Huguosi Traditional Chinese Medicine Hospital,Beijing 100035,China;Chinese Pharmaceutical Research International Science and Technology Cooperation Base of Yunnan University of Chinese Medicine,Kunming 650500,China;Institute of the History of Chinese Medicine and Medical Literature,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]北京中医药大学附属护国寺中医医院,北京100035 [2]云南中医药大学中药研究国际科技合作基地,云南昆明650500 [3]中国中医科学院中国医史文献研究所,北京100700

出　　处：《药物评价研究》2024年第11期2489-2498,共10页Drug Evaluation Research

基　　金：援鄂国家中医医疗队(金银潭医院)抗疫纪实研究课题(匹配)(ZZ150509);2020年高端科技创新智库青年项目—援鄂国家中医医疗队(金银潭医院)抗疫纪实研究课题(20200608CG080605);云南省“万人计划”青年拔尖人才专项(YNWR-QNBJ-2020-279);昆明市国际(对外)科技合作基地(GHJD-2021030)。

摘　　要：目的通过网络药理学探究杏仁-黄芩治疗新型冠状病毒肺炎(COVID-19)的作用靶点及信号通路,并阐述其作用机制。方法利用中药系统药理学数据库与分析平台(TCMSP)、BATMAN数据库筛选出杏仁-黄芩的活性成分及靶标;通过GeneCards数据库筛选COVID-19的预测靶点;将两者靶点进行映射,筛选出杏仁-黄芩药对与COVID-19相同的靶点,利用STRING数据库对这些共同靶点建立蛋白质-蛋白质互相作用(PPI)网络,并利用Metascape进行基因本体(GO)和京都基因与基因组百科全书(KEGG);利用Cytoscape3.7.2数据库构建活性成分-靶点网络图并筛选出核心靶点。结果根据筛选条件共获得杏仁-黄芩活性成分32个,潜在作用靶点137个,参与对炎症反应的调节等生物进程820个,结核、百日咳等通路82条。结论杏仁-黄芩药对通过多靶点、多通路起到抑制细胞因子风暴、止咳等药理作用,最终达到治疗COVID-19的效果。Objective To explore corona virus disease 2019(COVID-19)targets and signal pathways through the pharmacology of almond and scutellaria,and to explain the mechanism.Methods TCMSP and BATMAN databases were used to screen the active components and targets of Armeniacae Semen Amarum-Scutellariae Radix.Genecards database was used to screen the predicted targets of COVID-19.The two targets were mapped to screen out the same targets of almond Scutellaria and COVID-19.String was used to build PPI network for these common targets,and metascape was used for go biological process enrichment and KEGG pathway analysis.And the network map of active components and targets was constructed with the database of Cytoscape 3.7.2 and the core targets were screened out.Results According to the screening conditions,32 active components,137 potential targets,820 biological processes involved in the regulation of inflammatory response,82 pathways of tuberculosis and pertussis were obtained.Conclusion Armeniacae Semen Amarum-Scutellariae Radix can inhibit cytokine storm,cough and other pharmacological effects through multiple targets and channels,and finally achieve the therapeutic effect of COVID-19.

关 键 词：新型冠状病毒肺炎 网络药理学 杏仁 黄芩 细胞因子风暴 

分 类 号：R285.5[医药卫生—中药学]