黄芩苷药理活性和作用机制研究进展  

Research progress of pharmacological effects and mechanism of baicalin

作　　者：侯晓杰 张建锋 侯长周 周礼杰 代华 张石宇 李玮 HOU Xiaojie;ZHANG Jianfeng;HOU Changzhou;ZHOU Lijie;DAI Hua;ZHANG Shiyu;LI wei(School of Pharmacy,Guizhou University of Chinese Medicine,Guiyang 550025,China;China Guizhou Valid Pharmaceutical Co.,Ltd.,Guiyang 550014,China;Guizhou Traditional Chinese Medicine Processing Technology Inheritance Base,Guiyang 550014,China;School of Pharmacy,Guizhou University,Guiyang 550025,China;The First Affiliated Hospital,School of Pharmacy of Guizhou University,Guiyang 550001,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025 [2]贵州威利德制药有限公司,贵州贵阳550014 [3]贵州中药炮制技术传承基地,贵州贵阳550025 [4]贵州大学药学院,贵州贵阳550025 [5]贵州中医药大学第一附属医院,贵州贵阳550001

出　　处：《药物评价研究》2024年第11期2688-2696,共9页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(82360816);贵州省中医药管理局中医药、民族医药科学技术研究专项课题(QZYY-2024-188,QZYY-2021-084);贵州省中药炮制技术传承基地建设国家中医药科技项目[(2015)86号];贵州中医药大学研究生教育创新计划项目(YCXKYS2023034)。

摘　　要：黄芩苷是从唇形科双子叶植物黄芩Scutellaria baicalensis的干燥根中提取分离出来的一种黄酮类化合物,对黄芩苷的药理作用及机制研究的关注度越来越高,主要具有抗病毒、抗肿瘤、抗炎、抗菌、神经保护、抗氧化等药理活性,还具有抗抑郁、调节免疫、安胎、降压、镇痛等药理作用。为更充分开发黄芩苷的药用价值,对黄芩苷的主要药理活性和相关作用机制进行分类整理,旨在为黄芩苷的临床应用及新药研发提供科学依据。Baicalin is a flavonoid compound extracted and isolated from the dried roots of Scutellaria baicalensis,a dicotyledonous plant in the family Lamiaceae.The pharmacological effects and mechanisms of baicalin have received increasing attention,mainly exhibiting antiviral,anti-tumor,anti-inflammatory,antibacterial,neuroprotective,antioxidant and other pharmacological activities.It also has pharmacological effects such as antidepressant,immune regulation,miscarriage control,blood pressure reduction,and analgesia.In order to fully develop the medicinal value of baicalin,the main pharmacological activities and related mechanisms of action of baicalin are classified and organized,aiming to provide scientific basis for the clinical application and new drug development of baicalin.

关 键 词：黄芩苷 抗病毒 抗炎 抗菌 抗肿瘤 神经保护 抗氧化 

分 类 号：R285.5[医药卫生—中药学]