前列腺多参数磁共振成像对移行带前列腺癌的诊断研究  

Diagnostic study of prostate multiparametric magnetic resonance imaging in transitional zone prostate cancer

作　　者：张利 韩炜[2] 王帅帅 王保奇 Zhang Li;Han Wei;Wang Shuaishuai;Wang Baoqi(Department of Imaging,Yan′an City Hospital of Traditional Chinese Medicine,Yan′an 716000,China;Department of CT Diagnostics,Yan′an University Affiliated Hospital,Yan′an 716000,China;Department of Urinary Surgery,Yan′an City Hospital of Traditional Chinese Medicine,Yan′an 716000,China)

机构地区：[1]延安市中医医院影像科,延安716000 [2]延安大学附属医院CT诊断科,延安716000 [3]延安市中医医院泌尿外科,延安716000

出　　处：《中国临床实用医学》2024年第5期1-5,共5页China Clinical Practical Medicine

基　　金：延安市科技惠民计划项目(2017HM-07-05)。

摘　　要：目的探讨前列腺多参数磁共振成像(MRI)在移行带前列腺癌中的诊断价值。方法本研究为回顾性病例系列分析,选取2020年9月至2024年2月延安市中医医院经影像科检查的前列腺穿刺活检的132例男性患者,年龄(73.10±10.10)岁,年龄范围为52~88岁。根据病理结果将患者分为前列腺癌组(n=60)与良性病变组(n=72),均接受MRI检查,比较表观弥散系数(ADC)、T2WI评分、时间-信号强度曲线(TIC),采用logistic回归分析影响前列腺癌的危险因素,采用受试者操作特征(ROC)曲线构建预测模型。结果前列腺癌组患者标准化ADC值[(0.62±0.12)×10^(-3)mm^(2)·s^(-1)]、快速ADC值[(4.03±0.84)×10^(-3)mm^(2)·s^(-1)]、慢速ADC值[(0.91±0.19)×10^(-3)mm^(2)·s^(-1)]均低于良性病变组[(0.71±0.13)×10^(-3)mm^(2)·s^(-1)、(4.43±0.71)×10^(-3)mm^(2)·s^(-1)、(1.03±0.20)×10^(-3)mm^(2)·s^(-1)],前列腺癌组T2WI评分、TIC与良性病变组比较,差异有统计学意义(P<0.05)。logistic回归分析显示,低标准化ADC值、高T2WI评分和高TIC是影响前列腺癌的危险因素(P<0.001)。预测移行带前列腺癌的ROC曲线下面积为0.949(95%CI:0.916~0.981,P<0.001),灵敏度为93.33%,特异度为80.56%,阳性预测值为80.00%,阴性预测值为93.55%。结论MRI参数标准化ADC值、T2WI评分、TIC在诊断移行带前列腺癌中有较好的应用价值。ObjectiveTo explore the diagnostic value of prostate multiparametric magnetic resonance imaging(MRI)in transitional zone prostate cancer.MethodsThis study was a retrospective case series analysis,a total of 132 male patients who underwent prostate biopsy examined by the Imaging department at Yan′an City Hospital of Traditional Chinese Medicine from September 2020 to February 2024 were selected,the patients were aged(73.10±10.10)years old,and ranged in age from 52 to 88 years old.According to the pathological results,patients were divided into prostate cancer group(n=60)and benign lesion group(n=72),both of whom underwent MRI examination,the apparent diffusion coefficient(ADC),T2WI score,and timesignal intensity curve(TIC)were compared,logistic regression analysis was used to identify risk factors for prostate cancer,and a predictive model was constructed using receiver operating characteristic(ROC)curve.ResultsThe standardized ADC values[(0.62±0.12)×10^(-3)mm^(2)·s^(-1)],fast ADC values[(4.03±0.84)×10^(-3)mm^(2)·s^(-1)],and slow ADC values[(0.91±0.19)×10^(-3)mm^(2)·s^(-1)]in the prostate cancer group were all lower than those in the benign lesion group[(0.71±0.13)×10^(-3)mm^(2)·s^(-1),(4.43±0.71)×10^(-3)mm^(2)·s^(-1),(1.03±0.20)×10^(-3)mm^(2)·s^(-1)],the T2WI score and TIC of the prostate cancer group were compared with the prostate cancer group,the differences were statistically significant(P<0.05).Logistic regression analysis showed that low standardized ADC values,high T2WI scores,and high TIC were risk factors for prostate cancer(P<0.001).The area under the ROC curve for predicting transitional zone prostate cancer was 0.949(95%CI:0.916 to 0.981,P<0.001),sensitivity was 93.33%,specificity was 80.56%,positive predictive value was 80.00%,and negative predictive value was 93.55%.ConclusionsThe standardized ADC values,T2WI scores,and TIC curves of MRI parameters have good application value in the diagnosis of transitional zone prostate cancer.

关 键 词：移行带 前列腺癌 弥散加权成像 磁共振成像 表观弥散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]