宣白承气汤术前干预对结直肠癌患者术后肺功能、胃肠功能恢复的影响  

Effect of preoperative intervention with Xuanbai Chengqi Decoction on postoperative lung function and gastrointestinal function recovery of patients with colorectal cancer

作　　者：陈谦 于淼[1] CHEN Qian;YU Miao(General Surgery Department and Surgical Oncology Department,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院普外科及肿瘤外科,北京100010

出　　处：《北京中医药》2024年第11期1271-1274,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：北京市属医院科研培育计划项目(PZ2022008)。

摘　　要：目的观察对直肠癌患者术前采用宣白承气汤干预对术后康复的影响。方法选择2023年1月—2023年12月就诊于首都医科大学附属北京中医医院的结直肠恶性肿瘤患者60例,采用SAS9.4软件产生的随机序列将患者分为观察组与对照组各30例。术前7 d,观察组口服宣白承气汤,对照组口服安慰剂,1剂/d,早晚分服,200 mL/次,2组均以7 d为1个疗程。2组均行腹腔镜下结直肠癌根治术,术后给予常规治疗方案。比较2组术前1天及术后第7天的用力肺活量(FVC)、1秒用力呼气容积(FEV1)、FEV1/FVC等肺功能指标,术后首次肛门排气时间,术后首次排便时间,住院时间,并发症发生情况及安全性评价。结果术后第7天,观察组FEV1(2.40±0.39)L,显著高于对照组(2.12±0.46)L,FEV1/FVC(77.20±10.75)亦显著高于对照组(72.35±9.55)(P<0.05)。观察组术后首次肛门排气时间(61.27±17.75)h显著短于对照组(78.93±15.05)h(P<0.05),观察组术后首次排便时间(138.33±52.80)h显著短于对照组(191.43±69.23)h(P<0.05),观察组术后住院时间(7.27±1.64)d显著短于对照组(9.27±1.93)d(P<0.05)。2组术后4周内并发症发生率比较,差异无统计学意义(χ^(2)=0.357,P=0.424)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论术前应用宣白承气汤可有效促进结直肠癌患者术后肺功能、胃肠功能恢复。Objective To observe the effect of preoperative intervention with Xuanbai Chengqi Decoction on postoperative recovery in rectal cancer patients.Methods A total of 60 colorectal cancer patients who visited Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,from January to December 2023 were enrolled and randomly divided into an observation group and a control group(30 patients in each group)using random sequences generated by SAS 9.4 software.Seven days before surgery,the observation group was given Xuanbai Chengqi Decoction orally,and the control group was given a placebo,with 1 dose per day,divided into morning and evening doses of 200 mL each.Both groups received 7 days of treatment.All patients underwent laparoscopic radical resection for colorectal cancer and were given conventional postoperative treatment.The following parameters were compared between the two groups:pulmonary function indicators,including forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),and FEV1/FVC on the day before surgery and on the seventh postoperative day;first postoperative anal flatus time,first postoperative bowel movement time,length of hospital stay,incidence of complications,and safety evaluation.Results On the seventh postoperative day,the observation group showed a significantly higher FEV1(2.40±0.39)L than the control group(2.12±0.46)L,and the FEV1/FVC ratio(77.20±10.75)was also significantly higher in the observation group than in the control group(72.35±9.55)(P<0.05).The observation group had a significantly shorter time to first postoperative anal flatus(61.27±17.75)h than the control group(78.93±15.05)h(P<0.05),and the time to first postoperative bowel movement(138.33±52.80)h was also significantly shorter in the observation group than in the control group(191.43±69.23)h(P<0.05).The observation group had a significantly shorter hospital stay(7.27±1.64)days than the control group(9.27±1.93)days(P<0.05).There was no statistically significant difference in the incidence

关 键 词：宣白承气汤 结直肠癌 腹腔镜下结直肠癌根治术 术后康复 肺功能 胃肠功能 

分 类 号：R248.9[医药卫生—中医临床基础]