自血穴注疗法联合卡介苗多糖核酸治疗小儿支气管哮喘的临床研究  

Clinical Study on Self Blood Acupoint Injection Therapy Combined with BCG-PSN in Treatment of Children with Bronchial Asthma

作　　者：王筱薇 郑小亮 齐亚庆 梁浩 WANG Xiaowei;ZHENG Xiaoliang;QI Yaqing;LIANG Hao(Qingyang Maternal and Child Health Hospital of Gansu,Qingyang 745000,Gansu,China)

机构地区：[1]庆阳市妇幼保健医院,甘肃庆阳745000

出　　处：《辽宁中医杂志》2024年第12期64-67,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探究自血穴注疗法联合卡介苗多糖核酸治疗小儿支气管哮喘的临床疗效。方法选取庆阳市妇幼保健医院2020年1月—2022年1月收治的120例支气管哮喘患儿为研究对象,随机将其分为联合组和传统组各60例,给予传统组卡介苗多糖核酸治疗,联合组在传统组的基础上采用自血穴注疗法治疗,比较临床疗效,肺功能改善情况,日间症状积分,夜间症状积分以及生活质量积分变化,免疫功能相关指标水平变化及不良反应发生情况。结果联合组总有效率高于传统组(P<0.05);治疗后4周两组患儿第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、用力呼气流量(forced expiratory flow,FEF)水平均显著升高,且联合组显著高于传统组(P<0.05);日间症状积分和夜间症状积分均降低,生活质量积分升高,联合组显著优于传统组(P<0.05);治疗后CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平均显著升高,且联合组显著高于传统组(P<0.05);两组均未发生不良反应。结论自血穴注疗法联合卡介苗多糖核酸治疗小儿支气管哮喘安全高效,可广泛应用于临床。Objective To explore the clinical efficacy of self blood acupoint injection therapy combined with Bacille Calmette-Guérin vaccine(BCG)polysaccharide nucleic acid in the treatment of pediatric bronchial asthma.Methods A total of 120 children with bronchial asthma admitted to the hospital from January 2020 to January 2022 were selected as the research subjects.They were randomly divided into a combination group and a traditional group with 60 cases in each.The traditional group was treated with BCG polysaccharide nucleic acid,while the combination group was treated with self blood point injection therapy on the basis of the traditional group.Clinical efficacy,improvement of lung function,daytime symptom score,nighttime symptom score and changes in quality of life score were compared.The changes in immune function related indicators and occurrence of adverse reactions were observed.Results The total effective rate of the combination group was higher than that of the traditional group(P<0.05).After 4 weeks of treatment,the values of forced expiratory volume in the first second(FEV1)and forced expiratory flow(FEF)in both groups of children were significantly increased,and the values of the combination group were significantly higher than those of the traditional group(P<0.05).The daytime symptom score and nighttime symptom score were significantly reduced,and the quality of life score was significantly increased.The scores of the combination group were significantly better than those of the traditional group(P<0.05).After treatment,the levels of CD_(3)^(+),CD_(4)^(+)and CD_(4)^(+)/CD_(8)^(+)were significantly increased,and the levels of the combination group were significantly higher than those of the traditional group(P<0.05).No adverse reactions occurred in both groups.Conclusion The combination of self blood acupoint injection therapy and BCG polysaccharide nucleic acid therapy is safe and efficient in the treatment of pediatric bronchial asthma,and can be widely applied in clinical practice.

关 键 词：小儿支气管哮喘 卡介苗多糖核酸 自血穴注疗法 肺功能 免疫功能 

分 类 号：R256.1[医药卫生—中医内科学]