补阳还五汤对稳定型冠心病患者炎症因子及其肠道菌群的影响  

Effect of Buyang Huanwu Decoction(补阳还五汤)on Inflammatory Factors and Intestinal Flora in Patients with Stable Coronary Heart Disease

作　　者：梁春波 黄带发 蔡德珠 张聪 邱瑜 于芸菲 LIANG Chunbo;HUANG Daifa;CAI Dezhu;ZHANG Cong;QIU Yu;YU Yunfei(General Hospital of Northern Theater Command,Geriatric Center of National Center for Clinical Research of Geriatric Diseases,Shenyang 110016,Liaoning,China)

机构地区：[1]国家老年疾病临床研究中心,北部战区总医院老年医学中心,辽宁沈阳110016

出　　处：《辽宁中医杂志》2024年第12期86-89,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：全军医学科研十二五课题计划项目(cws11j296)。

摘　　要：目的探讨补阳还五汤对稳定型冠心病患者炎症因子及肠道菌群的影响。方法将132例稳定型冠心病患者随机分为对照组和研究组,每组66例。两组患者均给予常规对症治疗。对照组给予阿托伐他汀钙片每次10 mg,口服,1次/d;研究组在对照组基础上给予补阳还五汤每次100 mL,口服,2次/d。两组患者疗程均为8周。比较两组间临床疗效、血脂水平、血清炎症因子及氧化三甲胺(trimethylamine oxide,TMAO)含量、肠道乳酸杆菌、双歧杆菌、大肠杆菌及真菌数量以及不良反应发生率。结果对照组总有效率(86.36%,57/66)低于研究组总有效率(96.97%,64/66)(P<0.05)。与对照组比较,研究组治疗后治疗后血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-18(interleukin-18,IL-18)及TMAO含量较低,治疗后肠道乳酸杆菌、双歧杆菌数量较高,大肠杆菌及真菌数量较低,差异均有统计学意义(均P<0.05)。结论补阳还五汤治疗稳定型冠心病患者的临床疗效确切,能有效调节肠道菌群构成,抑制炎症反应,且安全性较高。Objective To investigate the effect of Buyang Huanwu Decoction(补阳还五汤)on inflammatory factors and intestinal flora in patients with stable coronary heart disease.Methods A total of 132 patients with stable coronary heart disease were randomly divided into control group and study group,66 cases in each group.Both groups received routine symptomatic treatment.The control group was given atorvastatin calcium tablets 10 mg each time,orally,once a day.On the basis of the control group,the study group was given Buyang Huanwu Decoction 100 mL each time,orally,twice a day.The course of treatment was 8 weeks in both groups.The clinical efficacy,blood lipid level,serum inflammatory factors and trimethylamine oxide(TMAO),the number of intestinal lactobacillus,bifidobacterium,Escherichia coli and fungi,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the control group(86.36%,57/66)was lower than that of the study group(96.97%,64/66)(P<0.05).Compared with those of the control group,the levels of serum high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-18(IL-18)and TMAO in the study group were lower after treatment,the numbers of intestinal lactobacillus and bifidobacterium were higher,and the numbers of Escherichia coli and fungi were lower after treatment.The differences were statistically significant(all P<0.05).The incidence of adverse reactions was 10.61%in the study group and 13.64%in the control group,and there was no significant difference between the two groups(P>0.05).Conclusion Buyang Huanwu Decoction has definite clinical efficacy in the treatment of patients with stable coronary heart disease,which can effectively regulate the composition of intestinal flora,inhibit inflammation,and has high safety.

关 键 词：补阳还五汤 稳定型冠心病 肠道菌群 炎症因子 

分 类 号：R256.2[医药卫生—中医内科学]