肌筋膜触发点针灸辅助倍他司汀注射液治疗颈源性头痛的疗效及对血清NO、TNF-α及睡眠质量的影响  

Efficacy of Acupuncture and Moxibustion at Myofascial Trigger Point Combined with Betahistine Injection in Treatment of Cervicogenic Headache and Impact on Serum NO and TNF-αand Sleep Quality

作　　者：邹敏[1] 唐毅[1] 李瞻 ZOU Min;TANG Yi;LI Zhan(Neijiang Hospital of Traditional Chinese Medicine,Neijiang 641000,Sichuan,China)

机构地区：[1]内江市中医医院,四川内江641000

出　　处：《辽宁中医杂志》2024年第12期162-165,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：内江市科技支撑计划项目(103)。

摘　　要：目的观察肌筋膜触发点针灸辅助倍他司汀注射液治疗颈源性头痛(cervicogenic headache,CEH)的疗效,并探究对血清一氧化氮(nitric oxide,NO)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及睡眠质量的影响。方法选取100例2021年9月—2023年3月于内江市中医医院康复治疗科收治的CEH患者作为研究对象,通过随机数字表法双盲法分为对照组和针灸辅助组各50例。对照组采取倍他司汀注射液治疗,研究组在对照组基础上加以肌筋膜触发点针灸辅助治疗,均连续治疗2周。比较两组患者的临床疗效,血清血管内皮因子NO和内皮素-1(endothelin 1,ET-1)水平,血清炎症因子TNF-α、白细胞介素-1(interleukin-1,IL-1)和白细胞介素-6(interleukin-6,IL-6)水平,睡眠质量、疼痛程度和颈椎活动程度。结果针灸辅助组患者临床疗效的总有效率为96.00%(49/50),显著高于对照组86.00%(43/50)(P<0.05);治疗后,两组患者ET-1、TNF-α、IL-1和IL-6水平以及匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、视觉模拟评分法(visual analogue scale,VAS)和颈椎活动度量表(range of motion,ROM)评分均比治疗前显著降低,且针灸辅助均显著低于对照组(P<0.05);两组患者NO水平比治疗前显著升高,且针灸辅助显著高于对照组(P<0.05)。结论肌筋膜触发点针灸辅助倍他司汀注射液治疗能够显著改善CEH患者临床症状,纠正内皮功能紊乱,抑制细胞炎性反应,提高睡眠质量,缓解疼痛程度和颈椎活动程度,提高整体临床疗效。Objective To observe the efficacy of acupuncture and moxibustion at myofascial trigger point combined with betahistine injection in the treatment of cervicogenic headache(CEH),and investigate the impact on serum nitric oxide(NO)and tumor necrosis factor-α(TNF-α)and sleep quality.Methods A total of 100 patients with CEH who were admitted to the Rehabilitation Department of Neijiang Hospital of Traditional Chinese Medicine from September 2021 to March 2023 were selected as the research subjects.They were divided into the control group and the auxiliary acupuncture and moxibustion group by random number table method,with 50 patients in each group.The control group was treated with betahistine injection,and the study group was treated with acupuncture and moxibustion at myofascial trigger point combined with betahistine injection.All patients were treated for 2 consecutive weeks.The two groups were compared in terms of clinical efficacy,levels of serum NO,endothelin 1(ET-1),TNF-α,interleukin-1(IL-1)and interleukin-6(IL-6),sleep quality,pain degree,and cervical range of motion.Results The total clinical response rate in the auxiliary acupuncture and moxibustion group(96.00%,49/50)was significantly higher than that in the control group(86.00%,43/50)(P<0.05).After treatment,the levels of ET-1,TNF-α,IL-1 and IL-6,Pittsburgh sleep quality index(PSQI)scores,visual analogue scale(VAS)scores and cervical range of motion(ROM)scores decreased significantly in the two groups.The above indicators in the acupuncture and moxibustion group were significantly lower than those in the control group(P<0.05).After treatment,NO levels in the two groups increased significantly,and NO level in the acupuncture and moxibustion group was significantly higher than that in the control group(P<0.05).Conclusion Acupuncture and moxibustion at myofascial trigger point combined with betahistine injection can significantly improve clinical symptoms of patients with CEH,correct endothelial dysfunction,inhibit inflammatory response,improve sleep qu

关 键 词：肌筋膜触发点针灸 倍他司汀 颈源性头痛 内皮功能 炎性反应 睡眠质量 

分 类 号：R25[医药卫生—中医内科学]