清热解毒汤联合火针治疗痰瘀凝结型粉刺的临床研究  

Clinical Study on Treatment of Acne with Phlegm and Blood Stasis by Qingre Jiedu Decoction(清热解毒汤)Combined with Fire Acupuncture

作　　者：邓婧靓 潘信信 周洋 DENG Jingliang;PAN Xinxin;ZHOU Yang(Department of Dermatology,Nanyang Second People′s Hospital,Nanyang 473009,Henan,China)

机构地区：[1]南阳市第二人民医院,河南南阳473009

出　　处：《辽宁中医杂志》2024年第12期166-169,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨清热解毒汤联合火针治疗痰瘀凝结型粉刺的疗效。方法选取124例2021年6月—2023年1月南阳市第二人民医院皮肤科收治的痰瘀凝结型粉刺患者作为研究对象,分为对照组与观察组各62例,方法为随机数字表法。对照组予以异维A酸软胶囊,观察组在对照组基础上给予清热解毒汤联合火针,以4周为1个周期,两组均维持治疗1个周期。比较两组临床症状消失时间,治疗前、治疗4周后皮损积分、炎症因子水平、血清激素及血常规水平,治疗4周后临床疗效,治疗期间不良反应发生情况。结果观察组和对照组患者治疗4周后的临床总有效率分别为95.16%(59/62)、80.65%(50/62),相较于对照组,观察组总有效率更高;与对照组比较,观察组结节、丘疹、囊肿、脓包各临床症状消失时间均相对更短;相较于治疗前,两组患者治疗4周后的皮损数量、大小、颜色、硬度、部位及疼痛程度各项评分、血清白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、游离睾酮(free testosterone,FT)、雌二醇(estradiol,E2)水平均降低,且相较于对照组,观察组更低(P<0.05)。两组外周血白细胞计数(white blood cell,WBC)、红细胞计数(red blood cell,RBC)水平治疗前、治疗4周后及组间比差异均没有统计学意义(P>0.05)。两组治疗期间均未发生明显不良反应。结论清热解毒汤联合火针治疗痰瘀凝结型粉刺可有效缩短其临床症状恢复时间,减轻机体炎症反应,调节其内分泌功能,改善患者皮损情况,疗效显著,对患者血常规影响较小,且安全性较高。Objective To explore the curative effect of Qingre Jiedu Decoction(清热解毒汤)combined with fire acupuncture on acne caused by phlegm and blood stasis.Methods A total of 124 patients with acne caused by phlegm and blood stasis admitted to the dermatology department of Nanyang Second People′s Hospital from June 2021 to January 2023 were selected as the research objects and divided into the control group and the observation group,62 cases in each group.The method was random number table method.The control group was given isotretinoin soft capsules,and the observation group was given Qingre Jiedu Decoction combined with fire needle on the basis of the control group,with a cycle of 4 weeks.Both groups maintained a cycle of treatment.The disappearance time of clinical symptoms,score of skin lesion,levels of inflammatory factors,serum hormones and blood routine before and after 4 weeks of treatment,clinical efficacy after 4 weeks of treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results After 4 weeks of treatment,the total clinical effective rates of patients in the observation group and the control group were 95.16%(59/62)and 80.65%(50/62),respectively,which was higher in the observation group than that in the control group.Compared with those of the control group,the clinical symptoms of nodules,papules,cysts and pustules in the observation group disappeared in a relatively shorter time.Compared with those before treatment,the scores of the number,size,color,hardness,location and degree of pain,serum interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),free testosterone(FT)and estradiol(E2)of the two groups decreased after 4 weeks of treatment,and compared with those of the control group,the levels of the observation group were lower(P<0.05).There was no significant difference in levels of white blood cell count(WBC)and red blood cell count(RBC)between the two groups before and after treatment for 4 weeks(P>0.0

关 键 词：粉刺 痰瘀凝结型 清热解毒汤 火针 疗效 

分 类 号：R275[医药卫生—中医皮科]