ERS在NASH发生发展中的作用及中医药调控ERS防治NASH的研究进展  

Research Progress on Role of ERS in Occurrence and Development of NASH and Prevention and Treatment of NASH by Traditional Chinese Medicine through ERS

作　　者：穆杰 雷娜 宋虹霏 曾玲 李岫滟 吴圣杰 李青峰 李乔[2] MU Jie;LEI Na;SONG Hongfei;ZENG Ling;LI Xiuyan;WU Shengjie;LI Qingfeng;LI Qiao(College of Basic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611130,Sichuan,China;West Area of The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611730,Sichuan,China)

机构地区：[1]成都中医药大学基础医学院,四川成都611130 [2]成都中医药大学附属第三医院西区,四川成都611730

出　　处：《辽宁中医杂志》2024年第12期203-210,共8页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年项目(82104655);四川省中医药管理局科学技术研究专项(2023MS074);成都中医药大学“杏林学者”学科人才科研提升计划项目(BSH2020016,XJ2022001101)。

摘　　要：非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)被公认为全球最主要的公共卫生问题之一,是肝纤维化、肝硬化和肝癌的重要风险因子,严重危害着人类健康。NASH疾病机制复杂,涉及了胰岛素抵抗、氧化应激、炎症反应、细胞凋亡、脂质代谢等多个生物学机制,而随着研究的深入,内质网应激(endoplasmic reticulum stress,ERS)在NASH发生、发展中的重要作用逐渐被揭示,不仅在于ERS易受脂过载信号影响而启动,还在于其与NASH“多重打击”间的密切联系,鉴于ERS逐渐被认为是NASH关键机制之一,越来越多的中药复方及单体防治NASH的效应机制研究也开始关注于ERS途径,因此该文分别对ERS与NASH“多重打击”间的密切联系及中药复方、单体通过ERS途径改善NASH的效应机制展开综述,以期为合理有效治疗NASH提供理论和实验研究依据。Non-alcoholic steatohepatitis(NASH)is recognized as one of the most significant public health issues worldwide.It is an important risk factor of liver fibrosis,cirrhosis and liver cancer,which seriously endangers human health.The mechanism of NASH disease is complex,and its biological mechanisms involve insulin resistance,oxidative stress,inflammatory response,cell apoptosis,lipid metabolism,etc.With the deepening of research,the important role of endoplasmic reticulum stress(ERS)in the occurrence and development of NASH has been gradually revealed.The reason is not only that ERS is susceptible to lipid overload signals and starts,but also due to its close connection with NASH“multiple strikes”.Given that ERS is gradually recognized as one of the key mechanisms of NASH,more and more studies on the effective mechanisms of traditional Chinese medicine formulas and monomers in preventing and treating NASH have also begun to focus on the ERS pathway.Therefore,this article reviewed the close relationship between ERS and NASH“multiple strikes”,as well as the mechanism by which traditional Chinese medicine formulae and monomers improve NASH through the ERS pathway,in order to provide theoretical and experimental research basis for the rational and effective treatment of NASH.

关 键 词：非酒精性脂肪性肝炎 内质网应激 炎症 细胞凋亡 多重打击 

分 类 号：R256.4[医药卫生—中医内科学]