基于“既病防变”脾肾同补法调控缺血性脑卒中PI3K/AKT通路相关蛋白表达的研究进展  

Research Progress on Regulation of PI3K/AKT Pathway Related Protein Expression by Spleen-Kidney Simultaneous Supplement Method Based on“Preventing Disease from Changing”in Ischemic Stroke

作　　者：王羽 李文武 徐青云 朱潇 苗琦[3] 雷烨 张怡敏 朱慧渊 WANG Yu;LI Wenwu;XU Qingyun;ZHU Xiao;MIAO Qi;LEI Ye;ZHANG Yimin;ZHU Huiyuan(College of Medical Technology,Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China;College of Basic Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China;Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China)

机构地区：[1]陕西中医药大学医学技术学院,陕西咸阳712046 [2]陕西中医药大学基础医学院,陕西咸阳712046 [3]陕西中医药大学第二附属医院,陕西咸阳712046 [4]陕西中医药大学附属医院,陕西咸阳712046

出　　处：《辽宁中医杂志》2024年第12期215-220,I0023,共7页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82174268);中西医结合治疗糖尿病血管病变创新团队项目(2020XKTD-C01);陕西中医药大学校级研究生质量提升工程专项(CXSJ202316)。

摘　　要：缺血性脑卒中(ischemic stroke,IS)是一种由于脑局部血液供应不足导致的急性脑血管疾病,具有高致残率及致死率的特点。IS的发病机制复杂,涉及细胞凋亡、兴奋性中毒、能量代谢紊乱、氧化应激和炎症反应等方面。在脑缺血半暗带区域,细胞死亡的主要形式是凋亡。磷脂酰肌醇3-激酶(phosphoinositide-3 kinase,PI3K)/蛋白激酶B(perine-threonine kinase,Akt)信号通路是调控IS细胞凋亡的关键通路之一。既往研究显示中医理论“既病防变”指导下的脾肾同补法是IS的基本治则,该治法通过激活PI3K/Akt通路调控神经细胞凋亡,既能针对IS基本病机进行治疗,又能防止疾病传变,疗效确切。文章拟以“既病防变”为基础,以脾肾同补法为切入点,针对PI3K/Akt通路调控IS细胞凋亡的研究进行综述,以期为后续相关基础研究及临床选方用药提供一定的思路和方法。Ischemic stroke(IS)is an acute cerebrovascular disease that results from insufficient blood supply in the brain and ischemic stroke has a high rate of disability and fatality.The pathogenesis of IS is complex,involving apoptosis,excitatory poisoning,energy metabolism disorder,oxidative stress and inflammatory reaction.Apoptosis is an important form of cell death in ischemic penumbra region.Phosphoinositide-3 kinase(PI3K)/perine-threonine kinase(Akt)signaling pathway IS one of the key pathways to regulate IS cell apoptosis.Previous studies have shown that the combination of spleen and kidney therapy under the guidance of the theory of traditional Chinese medicine“preventing disease from changing”IS the basic treatment.This therapy regulates nerve cell apoptosis by activating PI3K/Akt pathway,which can not only treat the basic pathogenesis of IS,but also prevent the disease from changing.This paper aims to review the studies on the regulation of IS cell apoptosis by PI3K/Akt pathway on the basis of"preventing disease from changing"and the spleen-kidney co-supplement method as the entry point,in order to provide certain ideas and methods for the subsequent relevant basic research and clinical prescription selection.

关 键 词：既病防变 脾肾同补 磷脂酰肌醇3-激酶(phosphoinositide-3 kinase PI3K)/蛋白激酶B(perine-threonine kinase Akt)通路 脑卒中 细胞凋亡 

分 类 号：R25[医药卫生—中医内科学]