冠心病患者外周血泛素水解酶22表达同疾病严重程度与SYNTAX评分的相关性研究  

Correlation between peripheral blood ubiquitin-specific protease 22 and disease severity and SYNTAX scores in patients with coronary heart disease

作　　者：蔡雄 李楠 张上仕 邹金荣 CAI Xiong;LI Nan;ZHANG Shangshi;ZOU Jinrong(The Third Department of Cardiology,Shangrao People's Hospital,Jiangxi Province,Shangrao334000,China)

机构地区：[1]江西省上饶市人民医院心内三科,江西上饶334000

出　　处：《中国当代医药》2024年第33期54-57,66,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202212731)。

摘　　要：目的探究冠心病患者外周血泛素水解酶22(USP-22)的表达情况,分析其与疾病严重程度及SYNTAX评分的相关性。方法选取2021年10月至2023年1月上饶市人民医院收治的180例冠心病患者与50名健康体检人员作为研究对象。所有冠心病患者均于上饶市人民医院进行冠状动脉造影与常规血液检查,根据疾病情况将其划分为稳定型心绞痛(SAP)组(n=59)、不稳定型心绞痛(UAP)组(n=51)、急性心肌梗死(AMI)组(n=70);并将选取的50名健康体检人员纳入健康对照组(n=50)。比较四组研究对象的USP-22表达水平,统计三组冠心病患者的SYNTAX评分,比较不同SYNTAX评分冠心病患者的USP-22表达水平,并采用Spearman相关性分析探究USP-22表达水平与SYNTAX评分、冠心病严重程度(疾病类型)的相关性。结果UAP组和AMI组的USP-22表达水平均高于健康对照组、SAP组,AMI组的USP-22表达水平高于UAP组,SAP组的USP-22表达水平高于健康对照组,差异有统计学意义(P<0.05)。AMI组的SYNTAX评分高于UAP组与SAP组,UAP组的SYNTAX评分高于SAP组,差异有统计学意义(P<0.05)。180例冠心病患者中,SYNTAX评分≤22分者63例,>22~<33分者71例,≥33分者46例。SYNTAX评分>22~<33分患者的USP-22表达水平高于≤22分患者,SYNTAX评分≥33分患者的USP-22表达水平高于≤22分与>22~<33分患者,差异有统计学意义(P<0.05)。USP-22的表达水平与SYNTAX评分(r=0.645)、冠心病严重程度(r=0.589)之间呈正相关(P<0.05)。结论冠心病患者的USP-22表达水平明显高于健康人群,且AMI患者的USP-22水平升高最为显著,USP-22水平同冠心病患者的SYNTAX评分存在正相关关系,可能可以反映患者的疾病变化情况。Objective To explore the expression of peripheral blood ubiquitin-specific protease 22(USP-22),and to analyze its correlation with disease severity and SYNTAX scores in patients with coronary heart disease.Methods A total of 180 patients with coronary heart disease admitted to Shangrao People's Hospital from October 2021 to January 2023 and 50 healthy physical examination persons were selected as the research objects.All patients with coronary heart disease underwent coronary angiography and routine blood tests in Shangrao People's Hospital,and they were divided into stable angina pectoris(SAP)group(n=59),unstable angina pectoris(UAP)group(n=51)and acute myocardial infarction(AMI)group(n=70)according to the condition of the disease.And the 50 healthy physical examination persons were selected as the healthy control group(n=50).The expression levels of USP-22 in the four groups were compared,and the SYNTAX scores of the three groups of patients with coronary heart disease were calculated.The expression levels of USP-22 in patients with coronary heart disease with different SYNTAX scores were compared.Spearman correlation analysis was used to explore the correlation between USP-22 expression level and SYNTAX score and the severity of coronary heart disease(disease type).Results The expression level of USP-22 in UAP group and AMI group were higher than those in healthy control group and SAP group,the expression level of USP-22 in AMI group was higher than that in UAP group,and the expression level of USP-22 in SAP group was higher than that in healthy control group,the differences were statistically significant(P<0.05).The SYNTAX score of AMI group was higher than those of UAP group and SAP group, and the SYNTAX score of UAP group was higher than that of SAP group, the differences were statistically significant (P<0.05). Among 180 patients with coronary heart disease, 63 patients had SYNTAX score≤22, 71 patients had SYNTAX score>22-<33, and 46 patients had SYNTAX score≥33. The expression level of USP-22 in patie

关 键 词：冠心病 泛素水解酶22 表达水平 心绞痛 急性心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]