派特灵治疗人乳头瘤病毒感染阴道壁低级别病变的远期效果  

Long term efficacy analysis of Paiteling in the treatment of low-grade lesions of the vaginal wall caused by human papillomavirus infection

作　　者：雷丽华 李风英 吴忧 王凤 王艺[5] 冯云华 LEI Lihua;LI Fengying;WU You;WANG Feng;WANG Yi;FENG Yunhua(Department of Quality Control Assessment,Yichun Emergency Rescue Center,Jiangxi Province,Yichun 336000,China;Department of Gynaecology and Obstetrics,Yichun Maternal and Child Health Hospital,Jiangxi Province,Yichun 336000,China;Jinrui Central Health Center,Yuanzhou District of Yichun City,Jiangxi Province,Yichun 336000,China;Department of Nephrology,Nanchang People's Hospital,Nanchang Third Hospital,Jiangxi Province,Nanchang 330006,China;Department of Health Management Physical Examination,Jiangxi Maternal and Child Health Hospital,Jiangxi Province,Nanchang 330006,China)

机构地区：[1]江西省宜春市紧急救援中心质控考核科,江西宜春336000 [2]江西省宜春市妇幼保健院妇产科,江西宜春336000 [3]江西省宜春市袁州区金瑞中心卫生院,江西宜春336000 [4]南昌市人民医院南昌市第三医院肾内科,江西南昌330006 [5]江西省妇幼保健院健康管理体检科,江西南昌330006

出　　处：《中国当代医药》2024年第33期79-82,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202410948)。

摘　　要：目的分析人乳头瘤病毒(HPV)感染阴道壁低级别病变应用派特灵治疗的远期效果。方法选取江西省妇幼保健院2020年1月至2021年12月收治的HPV阳性、阴道镜下组织病理学检查结果为阴道壁低级别病变的60例患者作为研究对象,按照随机数字表法的方法分为对照组(30例)和研究组(30例),对照组采用保妇康栓方法,研究组采用派特灵治疗方法。随访2年,比较两组HPV转阴情况、阴道上皮内瘤变(VAINI)转阴情况、液基薄层细胞检查(TCT)转归情况和不良反应。结果研究组患者随访第24个月的HPV转阴率高于同组随访第6个月,对照组患者随访第18、24个月的HPV转阴率高于同组随访第6个月,研究组患者随访第6、12、18、24个月的HPV转阴率高于对照组,差异有统计学意义(P<0.05)。两组患者随访第24个月的VAINI转阴率高于同组随访第6个月,研究组患者随访第6、12、18、24个月的VAINI转阴率高于对照组,差异有统计学意义(P<0.05)。研究组患者随访第24个月的TCT转归率高于同组随访第6、12、18个月,对照组患者随访第24个月的TCT转归率高于同组随访第6、12个月,研究组患者随访第6、12、18、24个月的TCT转归率高于对照组,差异有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论派特灵相较于保妇康栓治疗HPV感染阴道壁低级别病变,可提高HPV转阴率/阴道壁低级别病变的转阴率以及TCT转归率,且不会增加不良反应。Objective To analyze the long-term effects of using Pectin to treat low-grade lesions of the vaginal wall caused by human papillomavirus(HPV)infection.Methods A total of sixty patients with HPV positive and low-grade vaginal wall lesions were selected as the study subjects from January 2020 to December 2021 admitted to the Jiangxi Maternal and Child Health Hospital.They were divided into a control group(30 cases)and a study group(30 cases)according to random number table method.The control group received the Baofukang suppository method,while the study group received the Paitelin treatment method.Followed up for 2 years,the HPV seroconversion,vaginal intraepithelial neoplasia(VAINI)seroconversion,liquid based thin-layer cell test(TCT)outcome,and adverse reactions between the two groups were compared.Results The HPV conversion rate of patients in the study group at 24 months of follow-up was higher than that in the same group at 6 months of follow-up,and the HPV conversion rate of patients in the control group at 18 and 24 months of follow-up was higher than that in the same group at 6 months of follow-up and the HPV conversion rate of patients in the study group at 6,12,18,and 24 months of follow-up was higher than that of the control group,and the difference was statistically significant(P<0.05).The VAINI conversion rate of the two groups of patients at 24 months of follow-up was higher than that of the same group at 6 months of follow-up and the VAINI conversion rate of the study group patients at 6,12,18 and 24 months of follow-up was higher than that of the control group,and the difference was statistically significant(P<0.05).The TCT outcome rate of patients in the study group at 24 months of follow-up was higher than that of patients in the same group at 6, 12, and 18 months of follow-up and the TCT outcome rate of patients in the control group at 24 months of follow-up was higher than that of patients in the same group at 6 and 12 months of follow-up and the TCT outcome rate of patients in the study group

关 键 词：人乳头瘤病毒 派特灵 疗效 不良反应 

分 类 号：R711.73[医药卫生—妇产科学]