半导体激光治疗仪联合重组干扰素α-1b治疗呼吸道合胞病毒肺炎患儿的效果及对炎症因子的影响  

Effect of semiconductor laser therapeutic instrument combined with recombinant interferon α-1b on children with respiratory syncytial virus pneumonia and its influence on inflammatory factors

作　　者：韩菲[1] 葛励强 何鑫 徐汉云[1] 付睿[1] 周红平[1] HAN Fei;GE Liqiang;HE Xin;XU Hanyun;FU Rui;ZHOU Hongping(Department of Emergency,Jiangxi Children's Hospital,Jiangxi Province,Nanchang330006,China)

机构地区：[1]江西省儿童医院急诊科,江西南昌330006

出　　处：《中国当代医药》2024年第34期55-59,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202311013)。

摘　　要：目的探讨半导体激光治疗仪联合重组干扰素α-1b(IF-α-1b)治疗对呼吸道合胞病毒(RSV)肺炎患儿的效果及对炎症因子的影响。方法选取2022年9月至2023年9月江西省儿童医院收治的80例RSV患儿作为研究对象,采用随机数字表法分为观察组和对照组,每组各40例,对照组患儿给予IF-α-1b治疗,观察组患儿采用IF-α-1b联合半导体激光治疗,比较两组患儿的治疗效果、症状体征消失时间、治疗前后的血清炎症因子水平变化及不良反应情况;观察两组患儿在治疗前后的免疫因子水平。结果观察组的咳嗽减轻、呼吸恢复正常、啰音听诊消失、发热消失时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。观察组的临床总有效率高于对照组,差异有统计学意义(P<0.05)。两组患儿的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论半导体激光联合雾化吸入IF-α-1b治疗小儿RSV肺炎疗效确切,患儿临床症状改善时间和住院时间明显缩短,这与其调节炎症因子机制有关,值得临床推广。Objective To investigate the effect of semiconductor laser therapeutic instrument combined with recombinant interferonα-1b(IF-α-1b)on children with respiratory syncytial virus(RSV)pneumonia and its influence on inflammatory factors.Methods A total of 80 RSV children admitted to Jiangxi Children's Hospital from September 2022 to September 2023 were selected as the research objects,and they were divided into observation group and control group by random number table method,with 40 cases in each group.The control group was treated with IF-α-1b,and the observation group was treated with IF-α-1b combined with semiconductor laser.The treatment effect,disappearance time of symptoms and signs,changes in serum inflammatory factors before and after treatment,and adverse reactions were compared between the two groups.The levels of immune factors in the two groups before and after treatment were observed.Results The cough relief,respiration returned to normal,rales auscultation disappeared,fever disappeared time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Semiconductor laser combined with aerosol inhalation of IF-α-1b is effective in the treatment of children with R

关 键 词：重组干扰素Α-1B 肺炎患儿 半导体激光 呼吸道合胞病毒 啰音消失 炎症因子 

分 类 号：R725.6[医药卫生—儿科]